Differences in plasma gastrin, CEA, and CA 19-9 concentration in patients with proximal and distal colorectal cancer
Differences in plasma gastrin, CEA, and CA 19-9 concentration in patients with proximal and distal colorectal cancer
复制标题
DOI：
10.1385/ijgc:31:1-3:155
复制
发表时间：
2002-01-01
影响因子：
1.6
通讯作者：
Malecka-Panas, E
中科院分区：
文献类型：
--
作者：
Bombski, G;Gasiorowska, A;Malecka-Panas, E
瞄准我们研究了近端和远端结直肠癌患者血浆胃泌素与癌胚抗原（CEA）和癌抗原（CA）19-9相比是否存在差异。胃泌素浓度也进行了分析，依赖于肿瘤的阶段，以评估可能的预后作用，这种测量。对50例结肠癌患者进行空腹胃泌素、CA 19-9和CEA检测。远端肿瘤患者的平均血浆胃泌素水平为105.31 +/- 12.5 μ U/L，显著高于近端肿瘤患者（42.2 +/- 3.1 μ U/L）和对照组（p < 0.001）。近端肿瘤患者的平均血浆胃泌素与对照组之间无显著差异。远端肿瘤患者的平均CEA血浆水平（9.1 +/- 1.1 ng/mL）显著高于近端肿瘤患者（1.48 +/- 0.1 ng/mL）（p < 0.01）。同样，远端肿瘤患者的平均CA 19-9血浆水平（19.9 +/-2.1 U/mL）显著高于近端肿瘤患者（1.8 +/-0.2 U/mL）（p < 0.01）。杜克氏分期C、D组血浆胃泌素、CA 19-9、CEA水平均显著高于A、B组。我们推测，在远端和近端肿瘤患者中观察到的胃泌素浓度差异可能有助于这些癌症的不同发病机制和生物学特性。胃泌素作为结直肠癌诊断或预后指标的意义有待进一步研究。
Aim. We investigated whether there are differences in plasma gastrin, as compared with carcinoembryonic antigen (CEA) and cancer antigen (CA) 19-9 between patients with proximal and distal colorectal cancer. Gastrin concentration has also been analyzed, dependent on the tumor stage, in order to evaluate the possible prognostic role of this measurement.Methods. In 50 patients with colon cancer-fasting gastrin, CA 19-9 and CEA levels were evaluated.Results. Mean plasma-gastrin level in patients with distal tumor yielded 105.31 +/- 12.5 muU/L and was significantly higher than in patients with the proximal tumor site (42.2 +/- 3.1 muU/L) as well as in controls (p < 0.001). No significant difference was observed between mean plasma gastrin in patients with proximal tumors and the control group. The mean CEA plasma level was significantly higher (p < 0.01) in patients with distal tumors (9.1 +/- 1.1 ng/mL) than in those with proximal tumors (1.48 +/- 0.1 ng/mL). Similarly, the mean CA 19-9 plasma level was significantly higher (p < 0.01) in patients with distal tumor (19.9 +/- 2.1 U/mL) than in-those with proximal tumor: 1.8 +/- 0.2 U/mL. The mean gastrin plasma, CA 19-9, and CEA level was significantly higher in group of Duke's stage C and D as compared to A and B.Conclusion. We speculate that observed differences in gastrin concentration in patients with distal and proximal tumors may contribute to the distinct pathogenesis and biological properties of those cancers. The significance of gastrin as a marker for diagnostic or prognostic purposes in colorectal cancer requires further study.