Transcriptional Regulation of Antiviral Interferon-Stimulated Genes.
Transcriptional Regulation of Antiviral Interferon-Stimulated Genes.
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DOI：
10.1016/j.tim.2017.01.001
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发表时间：
2017-07
影响因子：
15.9
通讯作者：
Pan Q
中科院分区：
文献类型：
--
作者：
Wang W;Xu L;Su J;Peppelenbosch MP;Pan Q
Interferon-stimulated genes (ISGs) are a group of gene products that coordinately combat pathogen invasions, in particular viral infections. Transcription of ISGs occurs rapidly upon pathogen invasion, and this is classically provoked via activation of the Janus kinase/signal transducer and activator of transcription (JAK–STAT) pathway, mainly by interferons (IFNs). However, a plethora of recent studies have reported a variety of non-canonical mechanisms regulating ISG transcription. These new studies are extremely important for understanding the quantitative and temporal differences in ISG transcription under specific circumstances. Because these canonical and non-canonical regulatory mechanisms are essential for defining the nature of host defense and associated detrimental proinflammatory effects, we comprehensively review the state of this rapidly evolving field and the clinical implications of recently acquired knowledge in this respect. Transcriptional regulation of ISGs defines the state of host anti-pathogen defense. In light of the recently identified regulatory elements and mechanisms of the IFN–JAK–STAT pathway, new insights have been gained into this classical cascade in regulating ISG transcription. A variety of non-canonical mechanisms have been recently revealed that coordinately regulate ISG transcription. With regards to the adverse effects of IFNs in clinic, ISG-based antiviral strategy could be the next promising frontier in drug discovery.
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DOI：
10.1073/pnas.061487598
发表时间：
2001-03-13
影响因子：
11.1
作者：
DaFonseca, CJ;Shu, F;Zhang, JJ
通讯作者：
Zhang, JJ
影响因子：
13.5
作者：
Bitetto, Davide;Bortolotti, Nadia;Toniutto, Pierluigi
通讯作者：
Toniutto, Pierluigi
DOI：
10.1084/jem.20021553
发表时间：
2003-03-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bennett L;Palucka AK;Arce E;Cantrell V;Borvak J;Banchereau J;Pascual V
通讯作者：
Pascual V
影响因子：
30.5
作者：
Fenner, JE;Starr, R;Hertzog, PJ
通讯作者：
Hertzog, PJ
影响因子：
25.7
作者：
Chan, Henry L. Y.;Ahn, Sang Hoon;Cooney, Elizabeth
通讯作者：
Cooney, Elizabeth