Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrup.
Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrup.
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DOI：
10.3945/ajcn.2008.25825d
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Havel PJ
中科院分区：
文献类型：
--
作者：
Stanhope KL;Havel PJ
我们的实验室已经研究了两个关于果糖消费影响的假设：1）果糖消费的内分泌效应有利于正能量平衡，2）果糖消费促进致动脉粥样硬化脂质谱的发展。在以前的短期和长期研究中，我们证明了与葡萄糖饮料相比，在三餐中食用含果糖饮料会导致人体24小时血糖，胰岛素和瘦素的血浆浓度降低。我们还测试了长期食用高果糖饮食是否会导致热量摄入增加或能量消耗减少，从而导致体重增加和肥胖。在恒河猴中进行的一项研究的结果产生了模棱两可的结果。需要仔细控制和充分动力的长期研究来解决这些假设。在短期和长期研究中，我们证明了与葡萄糖饮料相比，果糖饮料的消费大大增加了餐后三酰甘油浓度。在长期研究中，摄入果糖的受试者载脂蛋白B浓度也增加，但摄入葡萄糖的受试者则没有。一项短期研究的数据比较了果糖、葡萄糖、高果糖玉米糖浆（HFCS）和蔗糖增甜的饮料的消费量，表明HFCS和蔗糖增加餐后三酰甘油的程度与单独使用100%果糖诱导的程度相当。随着肥胖、代谢综合征和2型糖尿病患病率的增加，含果糖饮料的消费量沿着增加，强调了在仔细控制的实验中研究果糖消费的代谢后果的重要性。
Our laboratory has investigated two hypotheses regarding the effects of fructose consumption: 1) The endocrine effects of fructose consumption favor a positive energy balance, and 2) Fructose consumption promotes the development of an atherogenic lipid profile. In previous short- and long-term studies, we demonstrated that consumption of fructose-sweetened beverages with 3 meals results in lower 24-hour plasma concentrations of glucose, insulin, and leptin in humans compared with consumption of glucose-sweetened beverages. We have also tested whether prolonged consumption of high-fructose diets could lead to increased caloric intake or decreased energy expenditure, thereby contributing to weight gain and obesity. Results from a study conducted in rhesus monkeys produced equivocal results. Carefully controlled and adequately powered long-term studies are needed to address these hypotheses. In both short- and long-term studies we demonstrated that consumption of fructose-sweetened beverages substantially increases postprandial triacylglycerol concentrations compared with glucose-sweetened beverages. In the long-term studies, apolipoproteinB concentrations were also increased in subjects consuming fructose, but not those consuming glucose. Data from a short-term study comparing consumption of beverages sweetened with fructose, glucose, high fructose corn syrup (HFCS) and sucrose, suggest that HFCS and sucrose increase postprandial triacylglycerol to an extent comparable to that induced by 100% fructose alone. Increased consumption of fructose-sweetened beverages along with increased prevalence of obesity, metabolic syndrome, and type 2 diabetes underscore the importance of investigating the metabolic consequences fructose consumption in carefully controlled experiments.