A thrombin inhibitor reduces brain edema, glioma mass and neurological deficits in a rat glioma model.
A thrombin inhibitor reduces brain edema, glioma mass and neurological deficits in a rat glioma model.
复制标题
DOI：
10.1007/978-3-7091-0651-8_103
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Y. Hua;R. Keep;T. Schallert;J. Hoff;G. Xi
中科院分区：
文献类型：
--
作者：
Y. Hua;R. Keep;T. Schallert;J. Hoff;G. Xi
虽然凝血酶是凝血级联反应中的关键酶，但它显然具有许多其他作用。因此，它可以诱导脑水肿形成、血管生成和细胞增殖。由于这三个因素在胶质瘤患者预后极差中的重要性，本研究检测了凝血酶在该疾病状态中的作用。我们发现凝血酶活性在大鼠胶质瘤模型中增加，并且凝血酶阳性细胞存在于肿瘤中。阿加曲班抗凝血酶治疗可减少脑水肿、肿瘤生长和肿瘤相关的神经功能缺损。我们的研究结果表明，凝血酶是胶质瘤治疗的新靶点。
Although thrombin is a critical enzyme in the coagulation cascade, it has become apparent that it has many other effects. Thus, it may induce brain edema formation, angiogenesis and cell proliferation. Because of the importance of these three factors in the extremely poor prognosis of glioma patients, the present study examined the role of thrombin in that disease state. We found that thrombin activity is increased in a rat glioma model and thrombin positive cells were present in the tumor. Anti-thrombin treatment with argatroban reduced brain edema, tumor growth, and tumorrelated neurological deficits. Our results suggest that thrombin is a new target for glioma treatment.