Bipolar disorder ANK3 risk variant effect on sustained attention is replicated in a large healthy population.
Bipolar disorder ANK3 risk variant effect on sustained attention is replicated in a large healthy population.
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DOI：
10.1097/ypg.0b013e328353ae79
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发表时间：
2012-08
影响因子：
0.9
通讯作者：
Stefanis NC
中科院分区：
文献类型：
--
作者：
Hatzimanolis A;Smyrnis N;Avramopoulos D;Stefanis CN;Evdokimidis I;Stefanis NC
独立的全基因组关联研究表明ANK3基因(Rs10994336)在双相情感障碍(BD)易感性中存在常见的单核苷酸多态，因此rs10994336标记被确定为BD的一个强有力的候选遗传因素。此外，最近的发现表明，这种变异通过影响持续注意力，影响了BD患者、他们未受影响的亲属和健康对照组的认知功能。在此，我们开始在基于人群的健康青年大样本(n=1808)中复制这一发现。持续注意用连续操作测验(CPT)评估，工作记忆用n-back任务评估。携带BD风险T等位基因的个体在目标检测中的敏感度显著降低，委托错误增加，反应潜伏期变异性不典型。此外，我们证实了rs10994336变异与工作记忆以及一般智能能力之间缺乏关联，这表明了对CPT成绩的特定影响。
Independent genome-wide association studies have implicated a common single nucleotide polymorphism within the ANK3 gene (rs10994336) in bipolar disorder (BD) susceptibility, thus establishing rs10994336 marker as a strong candidate predisposing genetic factor for BD. Furthermore, recent findings demonstrate that this variant impacts on cognitive functioning in BD patients, their unaffected relatives and healthy controls, by influencing sustained attention. Herein, we set out to replicate this finding in a large population-based sample of healthy young adults (n=1808). Sustained attention was evaluated with the Continuous Performance Test (CPT) as in the original study and working memory was assessed with the n-back task. Individuals carrying the BD risk T-allele showed significantly reduced sensitivity in target detection, increased errors of commission and atypical response latency variability. Additionally, we confirmed the lack of association between rs10994336 variant and working memory, as well as general intellectual ability, suggesting a specific effect on CPT performance.