High permeability cores to optimize the stimulation of deeply located brain regions using transcranial magnetic stimulation
High permeability cores to optimize the stimulation of deeply located brain regions using transcranial magnetic stimulation
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DOI：
10.1088/0031-9155/54/10/010
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发表时间：
2009-05
影响因子：
3.5
通讯作者：
R. Salvador;P. Miranda;Y. Roth;A. Zangen
中科院分区：
文献类型：
--
作者：
R. Salvador;P. Miranda;Y. Roth;A. Zangen
通过经颅磁刺激(TMS)有效地刺激深部脑区带来了许多挑战，这是因为感应场随着深度的增加而迅速衰减并且变得不那么集中。我们提出了一种新的方法来提高脑深部区域TMS的效率，该方法结合了高渗透率的核心，以增加聚焦和场强，并特别设计了一个线圈来诱导随着深度的增加而缓慢衰减的场。在一个真实形状的均匀头部模型上，使用有限元方法研究了该设计的性能，以确定该线圈/铁心布置所产生的总电场。计算表明，磁芯的加入使场强增加了25%，同时也降低了场沿特定方向随深度的衰减。以场的标准大于其最大值的面积来衡量焦点，在某些核心布置下也可提高15%之多。线圈的电感不会因铁芯而显著增加。这些结果表明，磁芯的存在可能会使这种特殊设计的线圈更适合于有效刺激大脑深层区域。
Efficient stimulation of deeply located brain regions with transcranial magnetic stimulation (TMS) poses many challenges, arising from the fact that the induced field decays rapidly and becomes less focal with depth. We propose a new method to improve the efficiency of TMS of deep brain regions that combines high permeability cores, to increase focality and field intensity, with a coil specifically designed to induce a field that decays slowly with increasing depth. The performance of the proposed design was investigated using the finite element method to determine the total electric field induced by this coil/core arrangement on a realistically shaped homogeneous head model. The calculations show that the inclusion of the cores increases the field's magnitude by as much as 25% while also decreasing the field's decay with depth along specific directions. The focality, as measured by the area where the field's norm is greater than of its maximum value, is also improved by as much as 15% with some core arrangements. The coil's inductance is not significantly increased by the cores. These results show that the presence of the cores might make this specially designed coil even more suited for the effective stimulation of deep brain regions.