Transcriptome profiling reveals a novel role for trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti‐silencing
Transcriptome profiling reveals a novel role for trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti‐silencing
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DOI：
10.1016/j.febslet.2011.06.036
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发表时间：
2011-08
期刊：
影响因子：
3.5
通讯作者：
Yakun Wan;Weiming Chen;J. Xing;Jinyin Tan;Bing Li;Huiying Chen;Zhanxian Lin;J. Chiang;Saleem Ramsey
中科院分区：
文献类型：
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作者：
Yakun Wan;Weiming Chen;J. Xing;Jinyin Tan;Bing Li;Huiying Chen;Zhanxian Lin;J. Chiang;Saleem Ramsey
组蛋白伴侣在染色质复制和转录过程中的组装和拆卸中起着重要作用。我们已经评估了组蛋白伴侣在酿酒酵母中的全局作用。基因芯片转录分析表明，组蛋白分子伴侣具有各自特异的靶基因，且不同的组蛋白分子伴侣在转录调控过程中具有部分重叠的功能。组蛋白去乙酰化酶抑制剂TSA和组蛋白伴侣Asf1、Vps75和Rtt106可以在平行途径中发挥作用以调节转录。此外，TSA可以特异性拮抗组蛋白伴侣Chz1介导的端粒抗沉默。本研究表明，组蛋白伴侣和组蛋白去乙酰化在转录调控中存在相互串扰机制。
The histone chaperones play an important role in chromatin assembly and disassembly during replication and transcription. We have assessed the global roles of histone chaperones in Saccharomyces cerevisiae. Microarray transcriptional analyzes indicate that histone chaperones have their own specific target genes, and various histone chaperones have partially overlapping functions during transcriptional regulation. The histone deacetylase inhibitor TSA and histone chaperones Asf1, Vps75 and Rtt106 can function in parallel pathways to regulate transcription. Moreover, TSA can specifically antagonize histone chaperone Chz1-mediated telomere anti-silencing. This study demonstrates that a mutual cross-talk mechanism exists between histone chaperones and histone deacetylation in transcriptional regulation.