Flanker compatibility effects in patients with Parkinson's disease: Impact of target onset delay and trial-by-trial stimulus variation
Flanker compatibility effects in patients with Parkinson's disease: Impact of target onset delay and trial-by-trial stimulus variation
复制标题
DOI：
10.1016/j.bandc.2006.09.002
复制
发表时间：
2007-04-01
影响因子：
2.5
通讯作者：
Friedrich, Frances J.
中科院分区：
文献类型：
--
作者：
Cagigas, Xavier E.;Filoteo, J. Vincent;Friedrich, Frances J.
帕金森病（PD）患者和健康对照组进行了侧翼任务，包括彩色目标和干扰物的介绍。要求参与者注意中心目标并识别其颜色。刺激显示是一致的（即，目标和侧翼是相同的颜色）或不一致。侧翼的开始和目标颜色之间的时间（目标开始延迟）或短或长。结果表明，PD患者和对照组在个体试验中的侧翼效应幅度没有差异，因为两组在短靶点起效延迟时均表现出典型的侧翼效应，两组在较长延迟时均未表现出侧翼效应。然而，当在逐个试验的基础上检查性能时，PD患者表现出相对于对照组的反应时间减慢，当必须在连续试验中以较长的试验间间隔做出相同的反应时，侧翼在连续试验中不一致，并且两次试验中的第二次试验的显示不一致。这些结果表明，PD患者在长时间的延迟抑制分心物受损，这种缺陷可能会影响这些患者的运动反应，这表明基底神经节有助于注意力和动作的界面。爱思唯尔公司出版
Parkinson's disease (PD) patients and healthy controls were administered a flanker task that consisted of the presentation of colored targets and distractors. Participants were required to attend to the center target and identify its color. The stimulus displays were either congruent (i.e., the target and flankers were the same color) or incongruent. The time between the onset of the flanker and the target color (the target onset delay) was either short or long. Results indicated that PD patients and controls did not differ in the magnitude of the flanker effect within individual trials in that both groups demonstrated a typical flanker effect at the short target onset delay and neither group demonstrated a flanker effect at the longer delay. However, when performance was examined on a trial-by-trial basis, PD patients demonstrated a slowing of reaction time relative to controls when having to make the same response across consecutive trials at longer inter-trial intervals when the flankers were incongruent across consecutive trials and the display on the second of two trials was incongruent. These results indicate that PD patients are impaired in inhibiting the distractors over an extended delay and that this deficit may impact motor responding in these patients, suggesting that the basal ganglia contribute to the interface of attention and action. Published by Elsevier Inc.