Reliability and validity of physical and mental health summary scores from the medical outcomes study HIV Health Survey
Reliability and validity of physical and mental health summary scores from the medical outcomes study HIV Health Survey
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DOI：
10.1097/00005650-199802000-00003
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发表时间：
1998-02-01
期刊：
影响因子：
3
通讯作者：
Wu, AW
中科院分区：
文献类型：
--
作者：
Revicki, DA;Sorensen, S;Wu, AW
目标.与健康相关的生活质量指标用于评估人类免疫缺陷病毒（HIV）/获得性免疫缺陷综合征（AIDS）新疗法临床试验中的患者结局。总结指数评分，而不是量表评分的轮廓，将简化数据分析和解释的结果，从临床试验和比较研究。使用两项针对艾滋病毒/艾滋病患者的新型抗逆转录病毒药物临床试验（总计n = 2253）和一项观察性研究（n = 162）的基线MOS艾滋病毒健康调查评分来制定身体健康摘要（PHS）和心理健康摘要（MHS）评分。探索性和验证性因素分析，以确定因素结构的基础上MOS艾滋病毒健康调查量表的总分。身体健康的总结和MHS分数的推导和因素结构证明不变的两组。PHS评分的可靠性为0.90至0.92，MHS评分为0.91至0.94。平均PHS和MHS评分在由HIV疾病分期、HIV疾病严重程度、Karnofsky体能状态评分和总体健康状况评分定义的患者组中存在差异。报告健康状况恶化的患者的平均PHS和MHS评分显著低于报告健康状况稳定或改善的患者。PHS和MHS在不同的艾滋病毒/艾滋病患者样本中具有重现性，是证明治疗对患者功能和福祉影响的可靠有效措施。
OBJECTIVES. Health-related quality of life measures are used to evaluate patient outcomes in clinical trials of new treatments for human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). Summary index scores, rather than profiles of scale scores, would simplify data analysis and interpretation of findings from clinical trials and comparison across studies.METHODS. Baseline MOS HIV Health Survey scores from two clinical trials of new antiretroviral medications in HIV/AIDS patients (total n = 2253) and an observational study (n = 162) were used to develop physical health summary (PHS) and mental health summary (MHS) scores. Exploratory and confirmatory factor analysis were used to identify the factor structure of the summary scores based on MOS HIV Health Survey scales. Physical health summary and MHS scores were derived and the factor structure proved invariant across the two groups.RESULTS. Reliability of the PHS score was 0.90 to 0.92 and MHS score was 0.91 to 0.94. Mean PHS and MHS scores differed in patient groups defined by HIV disease stage, HIV disease severity, Karnofsky performance status scores, and global ratings of health status. Mean PHS and MHS scores in patient reporting worsening health status were significantly lower than scores of patients reporting stable or improving health status.CONCLUSIONS. The PHS and MHS were reproducible across different samples of HIV/AIDS patients and are reliable and valid measures for demonstrating treatment impact on patient functioning and well-being.