Neuroimaging: In vivo imaging of the diseased nervous system

Neuroimaging: In vivo imaging of the diseased nervous system
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神经影像:患病神经系统的体内成像

DOI:
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发表时间:
2006
影响因子:
34.7
通讯作者:
M. Kerschensteiner
M. Kerschensteiner
中科院分区:
医学1区
文献类型:
--
作者:
T. Misgeld;M. Kerschensteiner

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活体显微镜是神经学研究的一个令人兴奋的工具,因为它可以揭示单个细胞如何对神经系统损伤做出反应。这有助于我们了解疾病是如何展开的,治疗是如何起作用的。在这里,我们回顾了用于可视化神经系统不同部分的光学成像技术,以及它们如何为神经系统疾病的病因学和治疗学提供了新的见解。我们的讨论集中在五个神经病理学领域(创伤、变性、缺血、炎症和癫痫),在活体显微镜中影响最大。我们讨论了该领域中具有挑战性的问题,并认为新的光学和非光学方法的融合将是克服这些挑战的必要手段。
In vivo microscopy is an exciting tool for neurological research because it can reveal how single cells respond to damage of the nervous system. This helps us to understand how diseases unfold and how therapies work. Here, we review the optical imaging techniques used to visualize the different parts of the nervous system, and how they have provided fresh insights into the aetiology and therapeutics of neurological diseases. We focus our discussion on five areas of neuropathology (trauma, degeneration, ischaemia, inflammation and seizures) in which in vivo microscopy has had the greatest impact. We discuss the challenging issues in the field, and argue that the convergence of new optical and non-optical methods will be necessary to overcome these challenges.
DOI: 10.1054/ceca.2001.0246
发表时间: 2001-12-01
期刊: CELL CALCIUM
影响因子: 4
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