Ten-year survival in women with primary stage IV breast cancer
Ten-year survival in women with primary stage IV breast cancer
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DOI：
10.1007/s10549-016-3974-x
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发表时间：
2016-11-01
影响因子：
3.8
通讯作者：
Dent, Rebecca
中科院分区：
文献类型：
--
作者：
Eng, Lee Guek;Dawood, Shaheenah;Dent, Rebecca
为了评估初发IV期乳腺癌患者10年的特定生存率，并确定其存活率是否随确诊年龄的不同而不同。我们检索了1990-2012年间监测、流行病学和最终结果18登记数据库中25,323名确诊为初发IV期乳腺癌的妇女的记录。对于每个病例，我们提取了诊断时的年龄、肿瘤大小、结节状态、雌激素受体状态、孕激素受体状态、种族、死亡原因和死亡日期的信息。在25323例IV期乳腺癌患者中，2542例(10.0%)在40岁或以下确诊，5562例(22.0%)在41~50岁之间确诊，219例(68.0%)在51~70岁之间确诊。经过平均2.2年的随访，16387名(64.7%)女性死于乳腺癌(中位生存期2.3年)。40岁及以下女性乳腺癌的10年生存率为15.7%，41-50岁女性为14.9%，51-70岁女性为11.7%(p<；0.0001)。在一项调整后的分析中，与51-70岁的女性相比，40岁及以下的女性(HR0.78；95%CI0.74-0.82p<；0.0001)和41-50岁的女性(HR0.82；95%CI0.79-0.85p<；0.0001)死于乳腺癌的风险显著降低。与老年女性相比，50岁之前被诊断为IV期乳腺癌的女性10年内存活率更高。
To evaluate breast cancer-specific survival at 10 years in patients who present with primary stage IV breast cancer, and to determine whether survival varies with age of diagnosis.We retrieved the records of 25,323 women diagnosed with primary stage IV breast cancer in the surveillance, epidemiology, and end results 18 registries database from 1990 to 2012. For each case, we extracted information on age at diagnosis, tumour size, nodal status, oestrogen receptor status, progesterone receptor status, ethnicity, cause of death and date of death. The Cox proportional hazards model was used to estimate the unadjusted and adjusted hazard ratio (HR) of death due to stage IV breast cancer, according to age group.Among 25,323 women with stage IV breast cancer, 2542 (10.0 %) were diagnosed at age 40 or below, 5562 (22.0 %) were diagnosed between ages 41 and 50 and 17,219 (68.0 %) were diagnosed between ages 51 and 70. After a mean follow-up of 2.2 years, 16,387 (64.7 %) women died of breast cancer (median survival 2.3 years). The ten-year actuarial breast cancer-specific survival rate was 15.7 % for women ages 40 and below, 14.9 % for women ages 41-50 and 11.7 % for women ages 51 to 70 (p < 0.0001). In an adjusted analysis, the risk of death from breast cancer at 10 years was significantly lower for women ages 40 and below (HR 0.78; 95 % CI 0.74-0.82; p < 0.0001) and for women ages 41-50 (HR 0.82; 95 % CI 0.79-0.85; p < 0.0001), compared to women ages 51-70.Approximately 13 % of women with primary stage IV breast cancer survive 10 years after diagnosis. Women diagnosed with stage IV breast cancer before age 50 have better survival at 10 years compared to older women.