Prodigiosin biosynthesis gene cluster in the roseophilin producer Streptomyces griseoviridis
Prodigiosin biosynthesis gene cluster in the roseophilin producer Streptomyces griseoviridis
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DOI：
10.1038/ja.2009.27
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发表时间：
2009-05-01
影响因子：
3.3
通讯作者：
Hayakawa, Yoichi
中科院分区：
文献类型：
--
作者：
Kawasaki, Takashi;Sakurai, Furni;Hayakawa, Yoichi
灰绿链霉菌2464-S5产生灵菌红素R1，一种三吡咯抗生素，和亲玫瑰素，一种结构上相关的化合物，含有两个吡咯和一个呋喃环。在S.灰绿菌属该簇由24个开放阅读框组成，包括与天蓝色链霉菌A3中红色簇中的灵菌红素生物合成基因同源的21个基因（rphD-rphZ）（2）。rphN在S.缺乏redN的天蓝色恢复了灵菌红素的产生。抗生素杂志（2009）62，271-276; doi：10.1038/ja.2009.27;发表于2009年3月27日
Streptomyces griseoviridis 2464-S5 produces prodigiosin R1, a tripyrrole antibiotic, and roseophilin, a structurally related compound containing two pyrrole and one furan rings. A gene cluster for the biosynthesis of a prodigiosin was identified in S. griseoviridis. The cluster consisted of 24 open reading frames, including 21 genes (rphD-rphZ) homologous to prodigiosin biosynthesis genes in the red cluster in Streptomyces coelicolor A3(2). The expression of rphN in S. coelicolor lacking redN restored the production of prodigiosin. The Journal of Antibiotics (2009) 62, 271-276; doi:10.1038/ja.2009.27; published on line 27 March 2009