Strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS): explanation and elaboration.
Strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS): explanation and elaboration.
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DOI：
10.1016/j.jclinepi.2011.02.003
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发表时间：
2011-08-01
影响因子：
7.2
通讯作者：
Khoury, Muin J
中科院分区：
文献类型：
--
作者：
Janssens, A Cecile J W;Ioannidis, John P A;Khoury, Muin J
复杂疾病的基因发现的快速和持续进展正在激发人们对遗传风险模型在临床和公共卫生实践中的潜在应用的兴趣。评估预测能力的研究数量正在稳步增加，但它们在报告的完整性和表面质量方面差异很大。透明地报告这些研究的优点和缺点对于促进遗传风险预测证据的积累非常重要。由人类基因组流行病学网络主办的一个多学科讲习班制定了一份清单，其中包括25个项目，建议在先前报告准则所确立的原则基础上加强遗传风险预测研究的报告。这些建议旨在提高研究报告的透明度、质量和完整性，从而改进对来自设计、实施或分析可能不同的多项研究的信息的综合和应用。
The rapid and continuing progress in gene discovery for complex diseases is fuelling interest in the potential application of genetic risk models for clinical and public health practice. The number of studies assessing the predictive ability is steadily increasing, but they vary widely in completeness of reporting and apparent quality. Transparent reporting of the strengths and weaknesses of these studies is important to facilitate the accumulation of evidence on genetic risk prediction. A multidisciplinary workshop sponsored by the Human Genome Epidemiology Network developed a checklist of 25 items recommended for strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS), building on the principles established by prior reporting guidelines. These recommendations aim to enhance the transparency, quality and completeness of study reporting, and thereby to improve the synthesis and application of information from multiple studies that might differ in design, conduct or analysis.