USE OF MENOPAUSAL ESTROGENS AND MEDROXYPROGESTERONE IN THE UNITED-STATES, 1982-1992
USE OF MENOPAUSAL ESTROGENS AND MEDROXYPROGESTERONE IN THE UNITED-STATES, 1982-1992
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DOI：
10.1016/0029-7844(94)00339-f
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发表时间：
1995-01-01
影响因子：
7.2
通讯作者：
BURKE, L
中科院分区：
文献类型：
--
作者：
WYSOWSKI, DK;GOLDEN, L;BURKE, L
目的：为了描述趋势的处方更年期雌激素和甲羟孕酮在美国。方法：每年估计的处方数量更年期雌激素和甲羟孕酮和描述性信息的患者和供应商，从两个医药市场研究数据库，国家处方审计和国家疾病和治疗指数IMS美国。结果：据估计，1982年有1360万张口服绝经期雌激素的处方，1992年有3170万张，增加了2.3倍（P = 0.0001）。1992年，倍美力是目前唯一被批准使用的口服结合雌激素，是美国最常用的品牌药物。1986年首次上市的经皮雌二醇Estraderm的处方从1987年的150万张增加到1992年的470万张。口服甲羟孕酮的处方也从1982年的230万张增加到1992年的1130万张，增加了4.9倍（P = 0.0001）。据估计，1992年，六分之一到四分之一的绝经后妇女服用绝经激素。这些药物主要是由妇产科医生。结论：绝经期雌激素和甲羟孕酮的使用在过去十年中大幅增加。这些趋势表明，美国妇女广泛暴露于更年期激素替代。
Objective: To describe trends in the prescription of menopausal estrogens and medroxyprogesterone in the United States.Methods: Annual estimates of the number of prescriptions for menopausal estrogens and medroxyprogesterone and descriptive information on patients and providers were obtained from two pharmaceutical marketing research data bases, the National Prescription Audit and the National Disease and Therapeutic Index of IMS America.Results: An estimated 13.6 million prescriptions were dispensed for oral menopausal estrogens in 1982, and 31.7 million in 1992, a 2.3-fold increase (P = .0001). In 1992 Premarin, the only oral conjugated estrogen currently approved for use, was the most frequently dispensed brand-name pharmaceutical in the United States. Dispensed prescriptions for Estraderm, a transdermal estradiol first marketed in 1986, increased from 1.5 million in 1987 to 4.7 million in 1992. Dispensed prescriptions for oral medroxyprogesterone also increased from 2.3 million prescriptions in 1982 to 11.3 million in 1992, a 4.9-fold increase (P = .0001). An estimated one in six to one in four postmenopausal women were taking menopausal hormones in 1992. These drugs were prescribed mainly by obstetrician-gynecologists.Conclusion: The use of menopausal estrogens and medroxyprogesterone has increased substantially over the past decade. These trends indicate that American women are widely exposed to menopausal hormone replacement.