Elevated serum fibrinogen/albumin ratios in patients with acute central serous chorioretinopathy
Elevated serum fibrinogen/albumin ratios in patients with acute central serous chorioretinopathy
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DOI：
10.1177/11206721221089773
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发表时间：
2022-03-21
影响因子：
1.7
通讯作者：
Akcay, Sezgin
中科院分区：
文献类型：
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作者：
Limon, Utku;Bozkurt, Erdinc;Akcay, Sezgin
目的探讨急性和慢性中心性浆液性脉络膜视网膜病变患者及健康对照者血清纤维蛋白原/白蛋白比值的变化。方法测定急性（第1组，30眼）和慢性（第2组，30眼）中心性浆液性脉络膜视网膜病变患者血清纤维蛋白原/白蛋白比值，并与健康对照组（第3组，30眼）进行比较。结果组1的纤维蛋白原/白蛋白比值（104.72 +/- 12.34）显著高于组2（75.83 +/- 10.06）和组3（72 +/- 9.54）（p = 0.001）。Pearson相关分析中，年龄、CMT和BCVA与纤维蛋白原/白蛋白比值之间无显著相关性。在ROC曲线分析中，急性CSCR的纤维蛋白原/白蛋白比值的最佳截止值为≥ 87.8，慢性CSCR的纤维蛋白原/白蛋白比值的最佳截止值为≥ 68.6。结论纤维蛋白原/白蛋白比值可作为急性CSCR患者治疗和随访期间全身炎症反应的生物标志物。
Purpose To evaluate the serum fibrinogen/albumin ratios in patients with acute and chronic central serous chorioretinopathy, and healthy control samples. Methods Serum fibrinogen/albumin ratios were assessed in patients with acute (Group-1, 30 eyes) and chronic (Group-2, 30 eyes) central serous chorioretinopathy, and compared with healthy control (Group-3, 30 eyes) samples. Results Fibrinogen/albumin ratios were significantly higher in Group-1 (104.72 +/- 12.34) than in Group-2 (75.83 +/- 10.06) and in Group-3 (72 +/- 9.54) (p = 0.001). No significant correlation was found between age, CMT, and BCVA with fibrinogen/albumin ratios in the Pearson correlation analysis. In the ROC curve analysis, the most appropriate cut-off value of the fibrinogen/albumin ratio for acute CSCR was >= 87.8 and the optimal cut-off value for the fibrinogen/albumin ratio for chronic CSCR was >= 68.6. Conclusion The fibrinogen/albumin ratio may be useful as an inflammatory biomarker to monitor the systemic inflammatory state during the treatment and follow-up in patients with acute CSCR.