The relationship of plasma Aβ levels to dementia in aging individuals with mild cognitive impairment
The relationship of plasma Aβ levels to dementia in aging individuals with mild cognitive impairment
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DOI：
10.1016/j.jns.2011.03.005
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发表时间：
2011-06-15
影响因子：
4.4
通讯作者：
Wang Qian
中科院分区：
文献类型：
--
作者：
Ma Fei;Wang Jianghua;Wang Qian
淀粉样β（A β）肽是阿尔茨海默病（AD）斑块的重要成分。A β 40和A β 42的CSF浓度降低是AD事件的潜在生物标志物。相反，血浆A β 40和A β 42浓度的研究产生了相互矛盾的结果。探讨老年轻度认知功能障碍（MCI）患者血浆A β 40和A β 42浓度与AD的关系，评价血浆A β及其比值作为AD进展标志物的敏感性和特异性。以及在4-6年的随访时间后，在临床和神经化学上被仔细分类为患有AD或其他痴呆的患者的血浆中它们的比率，所述患者来自MCI患者队列（n=588）。采用夹心酶联免疫吸附试验技术测定A β 40、A β 42的血浆浓度。使用考克斯比例风险模型评估血浆A β浓度与痴呆风险之间的关联。通过ROC曲线分析确定A β测量的最佳灵敏度和特异性。与认知稳定的MCI患者相比，发生AD的MCI患者基线时的血浆A β 42浓度和A β 42/A β 40比值显著降低。所有MCI组中A β 40的基线浓度相似。A β 42/A β 40比值在识别MCI早期AD方面上级A β 42浓度。A β 42与A β 40的比率而不是肽的绝对水平可以帮助识别MCI患者中的早期AD。血浆A β浓度作为早期痴呆标志物的潜在作用值得进一步研究。(C)2011爱思唯尔有限公司版权所有。
Amyloid beta(A beta) peptides are important components of plaques in Alzheimer's disease(AD). A decrease in the CSF concentration of A beta 40 and A beta 42 is a potential biomarker for incident AD. In contrast, studies on plasma A beta 40 and A beta 42 concentrations have yielded contradictory results. To explore the relationship between plasma A beta 40 and A beta 42 concentrations and AD in aging individuals with mild cognitive impairment (MCI), evaluate the sensitivity and the specificity of plasma A beta and their ratio as a marker for progression to AD.We measured baseline concentrations of A beta 40 and A beta 42, and their ratio in plasma of patients carefully categorized clinically and neurochemically as having AD or other dementias from a cohort of patients with MCI (n=588) after 4-6 years of follow-up time. Plasma concentrations of A beta 40, A beta 42 were measured using a sandwich enzyme-linked immunosorbent assay technology. The association between plasma A beta concentrations and the risk of dementia was assessed using cox proportional hazard models. Optimal sensitivity and specificity of A beta measurements were determined by ROC curve analysis. Plasma A beta 42 concentration and the A beta 42/A beta 40 ratio at baseline were significantly decreased in the MCI patients who developed AD as compared to cognitively stable MCI patients. The baseline concentrations of A beta 40 were similar in all MCI groups. The A beta 42/A beta 40 ratio was superior to A beta 42 concentration with regard to identify incipient AD in MCI. The ratio of A beta 42 to A beta 40 rather than absolute levels of the peptides can aid in the identification of incipient AD among MCI patients. A potential role of plasma A beta concentrations as a marker of incipient dementia warrants further investigation. (C) 2011 Elsevier B.V. All rights reserved.