Differences in behavioural test battery performance between mice with hippocampal and cerebellar lesions
Differences in behavioural test battery performance between mice with hippocampal and cerebellar lesions
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DOI：
10.1016/j.bbr.2006.06.016
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发表时间：
2006-10-02
影响因子：
2.7
通讯作者：
D'Hooge, Rudi
中科院分区：
文献类型：
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作者：
Goddyn, Hannelore;Leo, Sandra;D'Hooge, Rudi
海马或小脑病变的影响已被广泛描述，但对实验室小鼠进行行为测试以区分此类病变的能力尚未详细研究。我们比较了大的双边海马和半球小脑病变的行为后果与8个常用的测试，包括神经运动性能，探索行为，学习和记忆能力的元素。不同损伤的效应之间的分离最明显地表现为小脑损伤的神经运动障碍。小鼠（典型地在旋转棒任务中）和海马损伤小鼠中的活动过度（典型地在笼活动记录中）。来自测试电池的几个行为变量与海马和小脑病变的大小不同。相比之下，在Morris迷宫中没有发现这些病变的影响之间的绝对分离，据报道，Morris迷宫是一种依赖于大脑皮层的学习和记忆任务。另一方面，上下文恐惧条件反射任务确实揭示了在小脑损伤的小鼠中上下文依赖性冻结的选择性减少，而小脑损伤的动物显示出冻结反应的增加。总的来说，目前的一系列测试确实可以区分实验室小鼠小脑和海马损伤的影响。(c)2006 Elsevier B.V.保留所有权利。
Effects of hippocampal or cerebellar lesions have been described extensively, but the ability of behavioural tests for laboratory mice to distinguish between such lesions has not been studied in detail. We compared the behavioural consequences of large bilateral hippocampal and hemispheric cerebellar lesions with eight commonly used tests that included elements of neuromotor performance, exploratory behaviour, and learning and memory ability. Dissociation between the effects of the different lesions was most obviously demonstrated by neuromotor impairment in cerebellum-lesioned. mice (typically in the rotarod task) and hyperactivity in hippocampus-lesioned mice (typically in cage activity recordings). Several of the behavioural variables derived from the test battery correlated differently with the size of the hippocampal and cerebellar lesions. In contrast, no absolute dissociation between the effects of these lesions was found in the Morris maze, a reportedly hippocampus-dependent learning and memory task. The contextual fear conditioning task, on the other hand, did reveal a selective decrease of context-dependent freezing in hippocampus-lesioned mice, whereas cerebellum-lesioned animals displayed an increase in freezing responses. By and large, the present battery of tests does allow differentiation between the effects of cerebellar and hippocampal lesions in laboratory mice. (c) 2006 Elsevier B.V. All rights reserved.