Linear correlation between phenobarbital dose and concentration in alcohol withdrawal patients.
Linear correlation between phenobarbital dose and concentration in alcohol withdrawal patients.
复制标题
酒精戒断患者苯巴比妥剂量和浓度之间呈线性相关。
作者：
K. Tangmose;M. Nielsen;P. Allerup;J. Ulrichsen
简介
巴比妥类药物是治疗酒精戒断症状的有效药物，但存在服用过量和呼吸抑制的风险。本研究的目的是探讨长期酒精中毒患者戒断后苯巴比妥剂量与苯巴比妥血药浓度之间的相关性。
材料和方法
共有 497 名在 18 个月期间因酒精戒断症状住院治疗的患者参与了这项研究。根据观察到的症状，每 30 或 60 分钟口服苯巴比妥 200 mg。入院后24小时内，即上午8点，采集血液测定苯巴比妥浓度，并记录采血时苯巴比妥的累积剂量。
结果
采血时苯巴比妥的平均累积剂量为877mg+/-557mg，而平均血浆苯巴比妥浓度为104μmol/l+/-62μmol/l。对于男性和女性，苯巴比妥剂量和浓度之间存在统计上显着的线性相关性，因为药物浓度变化的 83% 和 84% 分别可以通过苯巴比妥剂量来解释。我们没有观察到苯巴比妥治疗的严重并发症，包括呼吸问题或严重镇静。
讨论
苯巴比妥剂量和浓度之间的强线性相关性表明，血浆苯巴比妥从胃肠道系统的吸收是高度可预测的。
INTRODUCTION
Barbiturates are potent drugs for treatment of alcohol withdrawal symptoms, but they entail a risk of over-dosage and respiratory depression. The purpose of the present study was to investigate the correlation between phenobarbital dose and phenobarbital blood concentration in patients withdrawing from long-term alcohol intoxication.
MATERIAL AND METHODS
A total of 497 patients who were hospitalized for treatment of alcohol withdrawal symptoms during an 18-month period were enrolled in the study. Phenobarbital 200 mg was administered orally every 30 or 60 minutes in response to the observed symptoms. Within the first 24 hours after admission, i.e. at 8 AM, blood was collected for determination of phenobarbital concentration, and the cumulated dose of phenobarbital at the time of the blood sampling was registered.
RESULTS
The mean cumulated phenobarbital dose at the time of the blood sampling was 877 mg +/- 557 mg, while the mean plasma phenobarbital concentration was 104 micromol/l +/- 62 micromol/l. A statistically significant linear correlation between phenobarbital dose and concentration was found for both males and females as 83% and 84% of the variation in drug concentration, respectively, could be explained by the phenobarbital dose. We observed no serious complications of the phenobarbital treatment--including respiratory problems or severe sedation.
DISCUSSION
The strong linear correlation between phenobarbital dose and concentration suggests that absorption of plasma phenobarbital from the gastrointestinal system is highly predictable.