DNA structure, mutations, and human genetic disease.
DNA structure, mutations, and human genetic disease.
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DNA 结构、突变和人类遗传疾病。
DOI：
10.1016/0958-1669(92)90005-4
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发表时间：
1992
影响因子：
7.7
通讯作者：
Wells,RD
中科院分区：
文献类型：
--
作者：
Sinden,RR;Wells,RD
脆性X综合征、肌强直性营养不良症和肯尼迪氏病的病因已被归因于大量扩增的三联体重复DNA序列。本文详细介绍了DNA结构多样性、二级结构或DNA定向诱变与三联体重复序列扩增之间的关系。
The etiology of fragile X syndrome, myotonic dystrophy and Kennedy's disease has been attributed to the massive expansion of triplet repeat DNA sequences. This review details the relationships between the structural diversity of DNA, its secondary structure or DNA-directed mutagenesis, and the expansion of triplet repeats.