Recent progress in the field of glycopeptide synthesis
Recent progress in the field of glycopeptide synthesis
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DOI：
10.1002/bip.20699
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发表时间：
2007-01-01
期刊：
影响因子：
2.9
通讯作者：
Nakahara, Yoshiaki
中科院分区：
文献类型：
--
作者：
Hojo, Hironobu;Nakahara, Yoshiaki
糖基化是一种常见的蛋白质翻译后修饰。尽管糖在生物系统中的重要性已被公认，但分析糖功能的方法还很有限。这是因为很难从天然资源中获得同质的糖蛋白。由于糖和肽化学的进步，各种适用于生物学研究的同质糖肽和糖蛋白的合成已经通过化学手段实现。本文对1999年以后糖肽合成领域的最新进展作一简要综述。(c)2007 Wiley Periodicals，Inc.
Glycosylation is a common post-translational modification of proteins. Although its significance in biological system is recognized, approaches to analyze carbohydrate function are limited. This is because of difficulty in obtaining homogenous glycoproteins from natural resources. Due to the progress of the carbohydrate and peptide chemistry, syntheses of various homogenous glycopeptides and glycoproteins, which are suitable for biological studies, have been achieved by chemical means. In this review, we briefly summarize recent advances in the field of glycopeptide synthesis after 1999. (c) 2007 Wiley Periodicals, Inc.