Physical activity and survival after colorectal cancer diagnosis
Physical activity and survival after colorectal cancer diagnosis
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DOI：
10.1200/jco.2006.06.0855
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发表时间：
2006-08-01
影响因子：
45.3
通讯作者：
Fuchs, Charles S.
中科院分区：
文献类型：
--
作者：
Meyerhardt, Jeffrey A.;Giovannucci, Edward L.;Fuchs, Charles S.
目的体力活动的个人有较低的风险发展为结直肠癌，但运动对癌症生存的影响是unknown.Patients和方法的前瞻性，观察性研究的573名妇女与I至III期结直肠癌，我们研究了结直肠癌的具体和总体死亡率根据预先定义的体力活动类别之前和之后的诊断和诊断后的活动变化。为了最大限度地减少隐匿性复发的偏倚，我们排除了在诊断后6个月内死亡的妇女，他们的体力活动assessment.Results的非转移性结直肠癌诊断后增加运动水平降低癌症特异性死亡率（趋势P = 0.008）和总死亡率（趋势P = 0.003）。与每周从事少于3个代谢当量任务[MET]小时的体力活动的女性相比，每周从事至少18个MET小时的女性结直肠癌特异性死亡率的校正风险比为0.39（95% CI，0.18至0.82），总死亡率的校正风险比为0.43（95% CI，0.25至0.74）。即使排除了在活动评估后12个月和24个月内死亡的妇女，这些结果也没有变化。诊断前体力活动不能预测死亡率。增加活动量的妇女（当比较诊断前和诊断后的值时）的风险比为0.48（95% CI，0.24 - 0.97），风险比为0.51（95% CI，0.30 - 0.85）对于全因死亡，结论I ~ III期结直肠癌患者确诊后，经常性体力活动可降低结直肠癌的发病风险。具体和总体死亡率。
Purpose Physically active individuals have a lower risk of developing colorectal cancer but the influence of exercise on cancer survival is unknown.Patients and Methods By a prospective, observational study of 573 women with stage I to III colorectal cancer, we studied colorectal cancer-specific and overall mortality according to predefined physical activity categories before and after diagnosis and by change in activity after diagnosis. To minimize bias by occult recurrences, we excluded women who died within 6 months of their postdiagnosis physical activity assessment.Results Increasing levels of exercise after diagnosis of nonmetastatic colorectal cancer reduced cancer-specific mortality (P for trend = .008) and overall mortality (P for trend = .003). Compared with women who engaged in less than 3 metabolic equivalent task [MET] -hours per week of physical activity, those engaging in at least 18 MET-hours per week had an adjusted hazard ratio for colorectal cancer-specific mortality of 0.39 (95% Cl, 0.18 to 0.82) and an adjusted hazard ratio for overall mortality of 0.43 (95% CI, 0.25 to 0.74). These results remained unchanged even after excluding women who died within 12 and 24 months of activity assessment. Prediagnosis physical activity was not predictive of mortality. Women who increased their activity (when comparing prediagnosis to postdiagnosis values) had a hazard ratio of 0.48 (95% CI, 0.24 to 0.97) for colorectal cancer deaths and a hazard ratio of 0.51 (95% CI, 0.30 to 0.85) for any-cause death, compared with those with no change in activity.Conclusion Recreational physical activity after the diagnosis of stages I to III colorectal cancer may reduce the risk of colorectal cancer-specific and overall mortality.