Feasibility demonstration of frequency domain terahertz imaging in breast cancer margin determination.
Feasibility demonstration of frequency domain terahertz imaging in breast cancer margin determination.
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DOI：
10.1117/12.907075
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发表时间：
2012-02-09
期刊：
影响因子：
--
通讯作者：
Khan A
中科院分区：
文献类型：
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作者：
Yngvesson SK;St Peter B;Siqueira P;Kelly P;Glick S;Karellas A;Khan A
在乳房保留手术中，外科医生试图将恶性组织沿着与周围的健康组织边缘一起移除。随后的病理分析确定这些边缘是否清除了恶性组织，这一过程通常需要至少一天。只有这样才能确定是否需要进行后续手术。就降低患者发病率、情绪压力和医疗保健而言，这种再次切除的可能性是不期望的。研究表明，乳腺标本的太赫兹（THz）图像可以准确地区分乳腺癌、正常纤维腺体组织和脂肪组织。该研究采用了时域光谱（TDS）技术。相反，我们正在开发一种新技术，频域太赫兹成像（FDTI）。在马萨诸塞大学/阿默斯特和马萨诸塞大学医学院/伍斯特（UMMS）之间的这个联合项目中，我们正在研究FDTI技术用于乳腺癌边缘THz反射成像的可行性。我们的系统，产生尺寸为2cm × 2cm的机械扫描图像，使用太赫兹气体激光器。该系统是校准与水和乙醇的混合物和反射系数低至1%已被测量。将展示来自UMMS乳腺癌肿块切除术的体模和标本的图像。最后，将讨论这种FDTI设置到用于手术室的紧凑且廉价的CMOS THz相机的可能过渡。
In breast conservation surgery, surgeons attempt to remove malignant tissue along with a surrounding margin of healthy tissue. Subsequent pathological analysis determines if those margins are clear of malignant tissue, a process that typically requires at least one day. Only then can it be determined whether a follow-up surgery is necessary. This possibility of re-excision is undesirable in terms of reducing patient morbidity, emotional stress and healthcare. It has been shown that terahertz (THz) images of breast specimens can accurately differentiate between breast carcinoma, normal fibroglandular tissue, and adipose tissue. That study employed the Time-Domain Spectroscopy (TDS) technique. We are instead developing a new technique, Frequency-Domain Terahertz Imaging (FDTI). In this joint project between UMass/Amherst and UMass Medical School/Worcester (UMMS), we are investigating the feasibility of the FDTI technique for THz reflection imaging of breast cancer margins. Our system, which produces mechanically scanned images of size 2cm × 2cm, uses a THz gas laser. The system is calibrated with mixtures of water and ethanol and reflection coefficients as low as 1% have been measured. Images from phantoms and specimens cut from breast cancer lumpectomies at UMMS will be presented. Finally, there will be a discussion of a possible transition of this FDTI setup to a compact and inexpensive CMOS THz camera for use in the operating room.