Structure, Synthesis and Inhibition Mechanism of Nucleoside Analogues as HIV‐1 Reverse Transcriptase Inhibitors (NRTIs)
Structure, Synthesis and Inhibition Mechanism of Nucleoside Analogues as HIV‐1 Reverse Transcriptase Inhibitors (NRTIs)
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HIV-1逆转录酶抑制剂（NRTIs）核苷类似物的结构、合成及抑制机制
DOI：
10.1002/cmdc.202000695
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发表时间：
2021
期刊：
影响因子：
3.4
通讯作者：
Abe Hiroshi
中科院分区：
文献类型：
--
作者：
Yoshida Yuki;Honma Masakazu;Kimura Yasuaki;Abe Hiroshi
获得性免疫缺陷综合征（AIDS）是由人类免疫缺陷病毒（HIV）感染引起的。虽然可以获得预防艾滋病毒感染的治疗，但艾滋病仍然是一种严重的疾病，每年造成许多人死亡。尽管已经合成并销售了多种抗HIV药物来治疗HIV感染患者，但核苷类似物逆转录酶抑制剂（NRTI），其模拟核苷，被广泛使用，并且仍然是药物化学家感兴趣的主题。然而，HIV已经获得了对NRTIs的耐药性，因此寻找新疗法的斗争仍在继续。在这篇综述中，我们跟踪的轨迹NRTIs，重点是合成，已开发的NRTIs的作用机制和应用。
Acquired immunodeficiency syndrome (AIDS) is caused by infection with the human immunodeficiency virus (HIV). Although treatments against HIV infection are available, AIDS remains a serious disease that causes many deaths annually. Although a variety of anti‐HIV drugs have been synthesized and marketed to treat HIV‐infected patients, nucleoside analogue reverse transcriptase inhibitors (NRTIs), which mimic nucleosides, are used extensively and remain a subject of interest to medicinal chemists. However, HIV has acquired drug resistance against NRTIs, and thus the struggle to find novel therapies continues. In this review, we trace the trajectory of NRTIs, focusing on the synthesis, mechanisms of action and applications of NRTIs that have been developed.