Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study
Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study
复制标题
DOI：
10.1093/cercor/bhab348
复制
发表时间：
2021-10-06
期刊：
影响因子：
3.7
通讯作者：
Del Percio, Claudio
中科院分区：
文献类型：
--
作者：
Babiloni, Claudio;Noce, Giuseppe;Del Percio, Claudio
在本回顾性和探索性研究中，我们验证了性别可能影响正常老年人和阿尔茨海默病和轻度认知障碍（ADMCI）患者静息状态闭眼脑电图（rsEEG）节律皮层来源的假设。69名ADMCI和57名Nold个体的数据集取自一个国际档案。在单个δ、θ和α频带以及固定β (14-30 Hz)和γ (30-40 Hz)频带研究rsEEG节律。每一组被分为匹配的女性和男性。性别因素影响老年人rsEEG源活动的大小。与男性相比，女性在所有皮质区域都有更大的α源活动。同样，admci女性的顶叶、颞叶和枕叶α源活动比男性更大。值得注意的是，目前的性别影响并不取决于核心遗传（APOE4）、神经病理学（脑脊液中A β 42/磷酸化tau比值）、结构神经退行性和脑血管（MRI）变量，这些变量表征了ADMCI老年人散发性ad相关过程。这些结果表明，性别因素可能显著影响神经生理的脑神经振荡同步机制，该机制支持在安静警戒期间产生主导的rsEEG α节律来调节皮质觉醒。
In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer's disease and mild cognitive impairment (ADMCI). Datasets in 69 ADMCI and 57 Nold individuals were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands and fixed beta (14-30 Hz) and gamma (30-40 Hz) bands. Each group was stratified into matched females and males. The sex factor affected the magnitude of rsEEG source activities in the Nold seniors. Compared with the males, the females were characterized by greater alpha source activities in all cortical regions. Similarly, the parietal, temporal, and occipital alpha source activities were greater in the ADMCI-females than the males. Notably, the present sex effects did not depend on core genetic (APOE4), neuropathological (A beta 42/phospho-tau ratio in the cerebrospinal fluid), structural neurodegenerative and cerebrovascular (MRI) variables characterizing sporadic AD-related processes in ADMCI seniors. These results suggest the sex factor may significantly affect neurophysiological brain neural oscillatory synchronization mechanisms underpinning the generation of dominant rsEEG alpha rhythms to regulate cortical arousal during quiet vigilance.