Transposable elements in early human embryo development and embryo models.
Transposable elements in early human embryo development and embryo models.
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DOI：
10.1016/j.gde.2023.102086
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发表时间：
2023-07
影响因子：
4
通讯作者：
Jonathan DiRusso;A. Clark
中科院分区：
文献类型：
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作者：
Jonathan DiRusso;A. Clark
转座因子（TE），长期以来被认为是“自私的基因组因子”，越来越多地被认为是基因组进化、基因组组织和基因调控的驱动因素。TE在早期胚胎发育中特别重要，其中干细胞技术的进步，以及改进的计算和下一代测序方法，为研究TE对早期哺乳动物发育的贡献提供了前所未有的机会。在这里，我们总结了我们在人类早期发育中对TE的理解，并扩展了如何利用新的基于干细胞的胚胎模型来增强这种理解。
Transposable elements (TEs), long discounted as ‘selfish genomic elements,’ are increasingly appreciated as the drivers of genomic evolution, genome organization, and gene regulation. TEs are particularly important in early embryo development, where advances in stem cell technologies, in tandem with improved computational and next-generation sequencing approaches, have provided an unprecedented opportunity to study the contribution of TEs to early mammalian development. Here, we summarize advances in our understanding of TEs in early human development and expand on how new stem cell-based embryo models can be leveraged to augment this understanding.