Dual Task Walking Reveals Cognitive Dysfunction in Community-dwelling Elderly Subjects: The Sefuri Brain MRI Study
Dual Task Walking Reveals Cognitive Dysfunction in Community-dwelling Elderly Subjects: The Sefuri Brain MRI Study
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DOI：
10.1016/j.jstrokecerebrovasdis.2014.05.008
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发表时间：
2014-08-01
影响因子：
2.5
通讯作者：
Yao, Hiroshi
中科院分区：
文献类型：
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作者：
Hashimoto, Manabu;Takashima, Yuki;Yao, Hiroshi
本研究的目的是探讨亚临床脑损伤和认知功能对社区老年受试者在有或没有并发认知任务的情况下步态表现的影响。没有痴呆的参与者（92名男性和109名女性，平均年龄67.8岁）接受了脑磁共振成像，神经心理学测试和步态测量。校正年龄、性别、教育和认知功能测试后，计时起身和行走测试的步态速度受损与深部白色病变（比值比[OR]，2.338; 95%置信区间[CI]，1.120-4.880）和糖尿病（OR，2.725; 95% CI，1.120-6.630）相关。双重任务行走的步态速度受损与年龄和Rivermead行为记忆测试评分相关（OR，高0.899/1分; 95%CI，0.813 - 0.994），而深部白色物质病变与双重任务行走无显著相关性。目前的研究表明，步态不仅代表身体功能，但亚临床认知功能障碍，特别是记忆障碍的健康老年人。
The aim of our study was to investigate the effects of subclinical brain lesions and cognitive function on gait performance with or without concurrent cognitive task in community-dwelling elderly subjects. Participants without dementia (92 men and 109 women with a mean age of 67.8 years) underwent brain magnetic resonance imaging, neuropsychologic tests, and gait measurements. Impaired gait velocity of the Timed Up and Go test was associated with deep white matter lesions (odds ratio [OR], 2.338; 95% confidence interval [CI], 1.120-4.880) and diabetes mellitus (OR, 2.725; 95% CI, 1.120-6.630) after adjusted for age, sex, education, and cognitive function tests. Impaired gait velocity of dual task walking was associated with age and the score of Rivermead Behavioral Memory Test (OR, .899/1 point higher; 95% CI,.813-.994), whereas deep white matter lesions were not significantly associated with dual task walking. The present study showed that gait represents not only physical functioning but also subclinical cognitive dysfunction particularly memory impairment in healthy elderly subjects.