Linking prenatal maternal adversity to developmental outcomes in infants: the role of epigenetic pathways.
Linking prenatal maternal adversity to developmental outcomes in infants: the role of epigenetic pathways.
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DOI：
10.1017/s0954579412000764
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发表时间：
2012-11
影响因子：
3.3
通讯作者：
Champagne FA
中科院分区：
文献类型：
--
作者：
Monk C;Spicer J;Champagne FA
产前暴露于母亲的压力，焦虑和抑郁可能会对婴儿的发育产生持久的影响，并导致精神病理学的风险。虽然产前母亲的痛苦的影响已经被很好地记录，通过母亲的心理社会变量形状的发展的潜在机制尚未得到充分阐明。分子生物学的进展突出了表观遗传机制在调节基因活性、神经生物学和行为方面的作用，以及环境诱导的表观遗传变异在将早期生命暴露与长期生物行为结果联系起来方面的潜在作用。在这篇综述中，我们讨论的证据表明，产妇产前窘迫和胎儿和婴儿的发育轨迹和表观遗传机制在介导这些影响的潜在作用之间的关联。出生后的经验可能有一个关键的调节影响产前的影响，在这里，我们回顾的结果说明产前产后的相互作用和产后母婴相互作用的发展和表观遗传的后果。子宫内环境受到胎盘功能的调节，有新的证据表明胎盘非常容易受到母体痛苦的影响，并且是表观遗传失调的目标。整合研究产前暴露，胎盘功能，产后产妇护理与表观遗传机制的探索，可能会提供新的见解孕产妇痛苦引起的病理生理学。
Prenatal exposure to maternal stress, anxiety, and depression can have lasting effects on infant development with consequences for risk of psychopathology. Though the impact of prenatal maternal distress has been well documented, the potential mechanisms through which maternal psychosocial variables shape development have yet to be fully elucidated. Advances in molecular biology have highlighted the role of epigenetic mechanisms in regulating gene activity, neurobiology, and behavior and the potential role of environmentally-induced epigenetic variation in linking early life exposures to long-term biobehavioral outcomes. In this review, we discuss evidence illustrating the association between maternal prenatal distress and both fetal and infant developmental trajectories and the potential role of epigenetic mechanisms in mediating these effects. Postnatal experiences may have a critical moderating influence on prenatal effects, and here we review findings illustrating prenatal-postnatal interplay and the developmental and epigenetic consequences of postnatal mother-infant interactions. The in utero environment is regulated by placental function and there is emerging evidence that the placenta is highly susceptible to maternal distress and a target of epigenetic dysregulation. Integrating studies of prenatal exposures, placental function, and postnatal maternal care with the exploration of epigenetic mechanisms may provide novel insights into the pathophysiology induced by maternal distress.