Cerebral hemodynamics during controlled hypotension induced by the continuous infusion of ganglionic blocking agents (hexamethonium, pendiomide and arfonad).
Cerebral hemodynamics during controlled hypotension induced by the continuous infusion of ganglionic blocking agents (hexamethonium, pendiomide and arfonad).
复制标题
连续输注神经节阻滞剂（六甲铵、Pendiomide 和 arfonad）引起的控制性低血压期间的脑血流动力学。
DOI：
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发表时间：
1954
影响因子：
15.9
通讯作者：
C. P. Smith
中科院分区：
文献类型：
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作者：
J. Moyer;G. Morris;C. P. Smith
虽然正常人对血压升高的急性脑血流动力学反应进行了研究[1]，但关于血压降低到低血压范围对脑血流动力学的影响的信息很少。全身血压的适度降低对脑循环的影响似乎很小。然而，当血压显著降低时，人们可能会预料到脑血管的代偿性血管扩张可能会超过。因此，本研究的主要目的是评估神经节阻滞剂降低血压对脑循环的影响。试图确定动脉血压降低的临界水平，如果超过这个临界值，进一步的抑郁可能会导致脑缺血和脑缺氧。由于目前在一些外科手术中使用控制性降压，因此这种类型的估计是特别有意义的。本研究对未麻醉受试者持续输注神经节阻滞剂6-甲溴胺、2-潘生丁、8-或阿方达降压的脑循环进行了观察。
Although the acute cerebral hemodynamic response to blood pressure elevation has been studied in normal man (1), there is very little information regarding the effect upon cerebral hemodynamics of reduction in blood pressure to hypotensive ranges. A moderate reduction in the systemic blood pressure appears to have very little effect on the cerebral circulation (2). However, when the blood pressure is markedly reduced one would anticipate that compensatory vasodilation of the cerebral vessels may be exceeded. Accordingly, the primary purpose of the current study was an estimation of the effect on the cerebral circulation of reduction in blood pressure produced by ganglionic blocking agents. An attempt was made to determine the critical level of reduction in arterial blood pressure beyond which further depression might produce cerebral ischemia and cerebral hypoxia. An estimation of this type is especially indicated because of the current use of controlled hypotension for some surgical procedures. The observations on the cerebral circulation in the current study were made on unanesthetized subjects in whom the blood pressure was reduced by continuous infusion of hexamethonium,2 Pendiomide,8 or Arfonad,4 all of which are ganglionic blocking agents.