Epidemiological Study of Pancreatic Diabetes in Japan in 2005 A Nationwide Study
Epidemiological Study of Pancreatic Diabetes in Japan in 2005 A Nationwide Study
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DOI：
10.1097/mpa.0b013e3181ca3da4
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发表时间：
2010-08-01
期刊：
影响因子：
2.9
通讯作者：
Shimosegawa, Tooru
中科院分区：
文献类型：
--
作者：
Ito, Tetsuhide;Otsuki, Makoto;Shimosegawa, Tooru
目的：胰型糖尿病的流行病学研究较少。在这项研究中，我们确定了胰腺糖尿病在日本的发病率和病理。方法：采用全国分层随机抽样方法对2005年日本胰腺糖尿病流行病学进行调查。我们特别关注与胰腺疾病（真正的胰腺糖尿病）发生相关的新发糖尿病。结果：接受治疗的真胰糖尿病患者共1.95万人，占糖尿病患者的0.8%。患病率估计为每10万人15.2例，年发病发生率为每10万人1.1例。在真胰糖尿病的并发症中，视网膜病变的发生率低于1型和2型糖尿病。在真胰型糖尿病合并慢性胰腺炎中，酒精性胰腺炎占最大比例。此外，53.7%的人持续饮酒，66.7%的人接受胰岛素治疗。接受胰岛素治疗的经常饮酒者出现低血糖的频率较高。低血糖是使用胰岛素和持续饮酒者死亡的主要原因。结论：明确了日本胰腺糖尿病的流行病学。慢性胰腺炎相关性胰腺糖尿病患者应接受以戒酒为重点的生活方式指导。
Objectives: There have been few epidemiological studies on pancreatic diabetes. In this study, we determined the incidence and pathology of pancreatic diabetes in Japan.Methods: We examined the epidemiology of pancreatic diabetes in Japan in 2005 by using a nationwide stratified random-sampling method. Especially, we focused on newly developed diabetes in association with the occurrence of pancreatic disease (true pancreatic diabetes).Results: A total of 19,500 individuals received treatment for true pancreatic diabetes, accounting for 0.8% of patients with diabetes. Prevalence was estimated to be 15.2 per 100,000 with an annual onset incidence of 1.1 per 100,000. With regard to the complications in true pancreatic diabetes, the incidence of retinopathy was lower than that in types 1 and 2 diabetes. Among true pancreatic diabetes with chronic pancreatitis, alcoholic pancreatitis was found in the largest sector. Furthermore, as many as 53.7% were continuous drinkers, and 66.7% received insulin therapy. The frequency of hypoglycemia was high in regular drinkers treated with insulin. Hypoglycemia was a major cause of death in patients who were on insulin and continuous drinkers.Conclusion: We clarified the epidemiology of pancreatic diabetes in Japan. Patients with chronic pancreatitis-associated pancreatic diabetes should receive lifestyle guidance focused on drinking cessation.