Biosynthesis: Is it time to go retro?
Biosynthesis: Is it time to go retro?
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DOI：
10.1038/nchembio.377
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发表时间：
2010-06-01
影响因子：
14.8
通讯作者：
Bachmann, Brian O.
中科院分区：
文献类型：
--
作者：
Bachmann, Brian O.
人工生物合成途径通常是从早期到后期逐步组装和优化的。这篇评论强调了受逆向进化假说和逆向合成概念启发，另一种回归方法用于生化途径设计和生成的潜力。除了作为途径设计工具之外，“生物逆合成”还具有作为构建和优化方法的潜力。
Artificial biosynthetic pathways are typically assembled and optimized progressively, from earlier to later steps. This commentary highlights the potential of an alternate regressive method for biochemical pathway design and generation, inspired by the retro-evolution hypothesis and the concept of retrosynthesis. In addition to being a pathway design tool,‘bioretrosynthesis’ has potential as a construction and optimization methodology.