Catalytic enantioselective aldol additions of α-isothiocyanato imides to aldehydes
Catalytic enantioselective aldol additions of α-isothiocyanato imides to aldehydes
复制标题
DOI：
10.1021/ja804838y
复制
发表时间：
2008-09-17
影响因子：
15
通讯作者：
Seidel, Daniel
中科院分区：
文献类型：
--
作者：
Li, Le;Klauber, Eric G.;Seidel, Daniel
报道了异硫氰酸酰亚胺与醛的高对映选择性的有机催化羟醛加成反应。这些反应提供了方便地获得对映体富集和保护的β-羟基-α-氨基酸，催化剂负载量低至1摩尔%。
Highly enantioselective organocatalytic aldol additions of aisothiocyanato imides to aldehydes are reported. These reactions provide convenient access to enantiomerically enriched and protected beta-hydroxy-a-amino acids with catalyst loadings as low as 1 mol%.