Paradoxes of the EphB1 receptor in malignant brain tumors.
Paradoxes of the EphB1 receptor in malignant brain tumors.
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EphB1受体在恶性脑肿瘤中的悖论
DOI：
10.1186/s12935-017-0384-z
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发表时间：
2017
影响因子：
5.8
通讯作者：
Ji S
中科院分区：
文献类型：
--
作者：
Wei W;Wang H;Ji S
Eph受体是受体酪氨酸激酶的一个亚家族。Eph受体介导的正向信号传导和ephrin配体介导的反向信号传导被称为双向信号传导。越来越多的证据表明Eph/ephrin信号通过细胞间通讯调节细胞迁移、粘附、形态变化、分化、增殖和存活。最近的一些研究已经开始涉及Eph/ephrin信号在肿瘤发生，转移和血管生成。以往的研究表明EphB 1受体及其配体ephrin在中枢神经系统中表达。EphB 1/ephrin信号在突触形成和成熟、神经祖细胞迁移、组织模式建立和免疫器官发育的调节中起重要作用。此外，最近的各种研究已经检测到EphB 1受体在不同脑肿瘤中的异常表达。然而，EphB 1/ephrins信号转导在这些肿瘤的发展中的潜在分子机制尚未完全理解。本文综述了EphB 1在某些脑肿瘤中的抑瘤和促瘤作用。了解EphB 1在脑肿瘤发生和转移中的细胞内机制可能为EphB 1靶向治疗的发展提供基础。
Eph receptors are a subfamily of receptor tyrosine kinases. Eph receptor-mediated forward and ephrin ligand-mediated reverse signalings are termed bidirectional signaling. Increasing evidence shows that Eph/ephrin signaling regulates cell migration, adhesion, morphological changes, differentiation, proliferation and survival through cell–cell communication. Some recent studies have started to implicate Eph/ephrin signaling in tumorigenesis, metastasis, and angiogenesis. Previous studies have shown that EphB1 receptor and its ephrin ligands are expressed in the central nervous system. EphB1/ephrin signaling plays an important role in the regulation of synapse formation and maturation, migration of neural progenitors, establishment of tissue patterns, and the development of immune organs. Besides, various recent studies have detected the abnormal expression of EphB1 receptor in different brain tumors. However, the underlying molecular mechanisms of EphB1/ephrins signaling in the development of these tumors are not fully understood. This review focuses on EphB1 that has both tumor-suppressing and -promoting roles in some brain tumors. Understanding the intracellular mechanisms of EphB1 in tumorigenesis and metastasis of brain tumors might provide a foundation for the development of EphB1-targeted therapies.