Releasing the brake on protein synthesis in hematopoietic stem cells.
Releasing the brake on protein synthesis in hematopoietic stem cells.
复制标题
释放对造血干细胞蛋白质合成的抑制。
DOI：
10.1016/j.stem.2021.06.003
复制
发表时间：
2021
期刊：
影响因子：
23.9
通讯作者：
Ruggero,Davide
中科院分区：
文献类型：
--
作者：
Forester,CraigM;Ruggero,Davide
蛋白质合成调控是指导造血干细胞分化的关键节点。在本期《细胞干细胞》中，Lv等人。(2021)描述了一种机制，通过控制60S和40S核糖体亚基的连接，通过靶向降解ZNF622来响应压力，从而微调翻译速率。
Protein synthesis regulation constitutes a key node in directing decisions between hematopoietic stemness and differentiation. In this issue ofCell Stem Cell, Lv et al. (2021) describe a mechanism by which HSCs fine-tune translation rates by controlling 60S and 40S ribosomal subunit joining through targeted degradation of ZNF622 in response to stress.