Solid-phase synthesis of heterocyclic nucleoside analogues: Substituted uracils tethered to isoxazoles, isoxazolines, and triazoles from a selenopolystyrene resin
Solid-phase synthesis of heterocyclic nucleoside analogues: Substituted uracils tethered to isoxazoles, isoxazolines, and triazoles from a selenopolystyrene resin
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杂环核苷类似物的固相合成：来自硒代聚苯乙烯树脂的取代尿嘧啶与异恶唑、异恶唑啉和三唑相连
DOI：
10.1021/cc800034v
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发表时间：
2008-07-01
影响因子：
--
通讯作者：
Huang, Xian
中科院分区：
文献类型：
--
作者：
Cao, Jian;Huang, Xian
通过固相有机合成构建了尿嘧啶N1与异恶唑、异恶唑啉和三唑以及尿嘧啶N3与异恶唑啉和异恶唑相连的杂环核苷类似物文库。该策略为生成用于生物筛选的杂环核苷类似物小型文库开辟了道路。
A heterocyclic nucleoside analogue library of uracils N1 tethered to isoxazoles, isoxazolines, and triazoles and uracil N3 tethered to isoxazolines and isoxazoles was constructed by solid-phase organic synthesis. This strategy opens the way for the generation of small libraries of heterocyclic nucleoside analogues for biological screening.