A Perspective on Neuronal Cell Death Signaling and Neurodegeneration
A Perspective on Neuronal Cell Death Signaling and Neurodegeneration
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DOI：
10.1007/s12035-010-8128-2
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发表时间：
2010-08-01
影响因子：
5.1
通讯作者：
Morfini, Gerardo
中科院分区：
文献类型：
--
作者：
Brady, Scott;Morfini, Gerardo
虽然通过凋亡途径的神经元细胞死亡代表了铁代谢异常的共同特征，但与非神经元细胞相似的典型凋亡变化是晚期事件。神经元功能的丧失发生在非常早的时间，当基于突触的神经元连接失败时。在这种情况下，凋亡途径通常可能起到清除作用，而不是致病作用。重新考虑神经系统中的细胞死亡，包括轴突变性的早期阶段，提供了一个更好的理解在神经退行性疾病中的各种凋亡信号通路所发挥的作用。专注于启动最终导致神经元损失的序列的疾病特异性机制，应有助于开发保护神经元功能和神经元数量的疗法。
Although neuronal cell death through apoptotic pathways represents a common feature of dysferopathies, the canonical apoptotic changes familiar from nonneuronal cells are late events. Loss of neuronal function occurs at a much early time, when synaptic-based neuronal connectivity fails. In this context, apoptotic pathways may normally serve a cleanup role, rather than a pathogenic one. Reframing the consideration of cell death in the nervous system to include the early stages of axonal degeneration provides a better understanding of the roles played by various apoptotic signaling pathways in neurodegenerative diseases. Focusing on disease-specific mechanisms that initiate the sequence that eventually leads to neuronal loss should facilitate development of therapies that preserve neuronal function and neuronal numbers.