Asnovolins A-G, Spiromeroterpenoids Isolated from the Fungus Aspergillus novofumigatus, and Suppression of Fibronectin Expression by Asnovolin E
Asnovolins A-G, Spiromeroterpenoids Isolated from the Fungus Aspergillus novofumigatus, and Suppression of Fibronectin Expression by Asnovolin E
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DOI：
10.1021/acs.jnatprod.6b00013
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发表时间：
2016-09-01
影响因子：
5.1
通讯作者：
Hosoe, Tomoo
中科院分区：
文献类型：
--
作者：
Ishikawa, Kazuki;Sato, Fumiaki;Hosoe, Tomoo
从 Aspergillus novofumigatus CBS117520 中分离出七种新型螺旋萜类化合物 asnovolins A-G (1-7)，其中一种可抑制纤连蛋白表达，以及一种已知化合物 novofumigatonin (8)。使用 MS 和 2D-NMR 数据阐明了 asnovolins A-G 的结构。 Asnovolin E (5) 抑制正常人新生儿真皮成纤维细胞的纤连蛋白表达。
Seven novel spiromeroterpenoids, asnovolins A-G (1-7), one of which was shown to suppress fibronectin expression, were isolated from Aspergillus novofumigatus CBS117520 along with a known compound, novofumigatonin (8). The structures of asnovolins A-G were elucidated using MS and 2D-NMR data. Asnovolin E (5) suppressed fibronectin expression by normal human neonatal dermal fibroblast cells.