Converging evidence for gamma synchrony deficits in schizophrenia.
Converging evidence for gamma synchrony deficits in schizophrenia.
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DOI：
10.1016/b978-0-7020-5307-8.00011-9
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Mathalon DH
中科院分区：
文献类型：
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作者：
Roach BJ;Ford JM;Hoffman RE;Mathalon DH
在听觉稳态反应（ASSR）的脑电图（EEG）研究中，精神分裂症患者表现出功率和/或锁相的缺陷，特别是在这些反应共振的40 Hz频率处。此外，由单音引起的瞬时伽马波段反应（GBR）的研究揭示了精神分裂症中伽马功率和锁相的缺陷。我们研究了40 Hz ASSR和瞬时GBR到单音的相关程度，以及它们是否评估了精神分裂症中重叠或不同的伽马带异常。对28例精神分裂症或情感性精神障碍（SZ）患者和25例年龄、性别匹配的健康对照者（HC）进行了40 Hz ASSR和听觉oddball范式下的EEG记录。ASSR由500 ms短声诱发，GBR由标准音诱发。伽马相位和幅度值，使用Morlet小波变换计算，用于获得总功率和锁相措施。相对于HC，SZ患者的总伽马功率和锁相ASSR和GBR为基础的措施有显着的赤字。在两组中，40 Hz ASSR和GBR锁相测量值显着相关，总功率测量值也存在类似的趋势。此外，GBR的共变大大降低了40 Hz ASSR功率和组间锁相差异。40 Hz ASSR和瞬态GBR测量提供了非常相似的信息，听觉伽玛异常精神分裂症，尽管整体增强40 Hz ASSR总功率和锁相值相对于相应的GBR值。
In electroencephalogram (EEG) studies of auditory steady-state responses (ASSR), patients with schizophrenia show a deficit in power and/or phase-locking, particularly at the 40Hz frequency where these responses resonate. In addition, studies of the transient gamma band response (GBR) elicited by single tones have revealed deficits in gamma power and phase-locking in schizophrenia. We examined the degree to which the 40 Hz ASSR and the transient GBR to single tones are correlated and whether they assess overlapping or distinct gamma band abnormalities in schizophrenia. EEG was recorded during 40 Hz ASSR and auditory oddball paradigms from 28 patients with schizophrenia or schizoaffective disorder (SZ) and 25 age- and gender-matched healthy controls (HC). The ASSR was elicited by 500 ms click trains, and the transient GBR was elicited by the standard tones from the oddball paradigm. Gamma phase and magnitude values, calculated using Morlet Wavelet transformations, were used to derive total power and phase-locking measures. Relative to HC, SZ patients had significant deficits in total gamma power and phase-locking for both ASSR- and GBR-based measures. Within both groups, the 40 Hz ASSR and GBR phase-locking measures were significantly correlated, with a similar trend evident for the total power measures. Moreover, co-varying for GBR substantially reduced 40 Hz ASSR power and phase-locking differences between the groups. 40 Hz ASSR and transient GBR measures provide very similar information about auditory gamma abnormalities in schizophrenia, despite the overall enhancement of 40 Hz ASSR total power and phase-locking values relative to the corresponding GBR values.