Physical activity as treatment for alcohol use disorders (FitForChange): study protocol for a randomized controlled trial
Physical activity as treatment for alcohol use disorders (FitForChange): study protocol for a randomized controlled trial
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DOI：
10.1186/s13063-017-2435-0
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发表时间：
2018-02-14
期刊：
影响因子：
2.5
通讯作者：
Andreasson, Sven
中科院分区：
文献类型：
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作者：
Hallgren, Mats;Andersson, Victoria;Andreasson, Sven
背景：酒精使用障碍（AUDs）的求助率很低，传统的治疗方法往往被认为是污名化的。体育活动对身心健康有积极影响，可使这一人群受益。我们建议比较有氧训练，瑜伽，和平时的护理AUDs在身体不活跃的瑞典adults.Methods的影响：这是一个三组，平行，单盲，随机对照试验（RCT）。总共有210名被诊断患有AUD的成年人（年龄在18-75岁之间）将被邀请参加为期12周的干预。主要研究结果是通过时间轴随访方法和酒精使用障碍识别测试（AUDIT）测量酒精消耗量。次要结局包括：抑郁、焦虑、感知压力、睡眠质量、身体活动水平、健身、自我效能、健康相关生活质量和认知。将采集血液样本以客观评估重度饮酒，并采集唾液以测量皮质醇。急性影响的冲动，饮酒，情绪和焦虑的运动也将assessed.Discussion：运动在AUD的治疗潜力是巨大的，因为许多人的疾病是身体不活跃，并有共病的健康问题。这项研究是第一个评估体力活动作为AUD独立治疗的影响的研究。将给予相当大的关注，以优化运动坚持。运动干预在AUD中的可行性和治疗效果将被讨论。Karolinska Institutet的伦理审查委员会（EPN）已批准该研究（DNR：2017/1380-3）。
Background: Help-seeking for alcohol use disorders (AUDs) is low and traditional treatments are often perceived as stigmatizing. Physical activity has positive effects on mental and physical health which could benefit this population. We propose to compare the effects of aerobic training, yoga, and usual care for AUDs in physically inactive Swedish adults.Methods: This is a three-group, parallel, single-blind, randomized controlled trial (RCT). In total, 210 adults (aged 18-75 years) diagnosed with an AUD will be invited to participate in a 12-week intervention. The primary study outcome is alcohol consumption measure by the Timeline Follow-back method and the Alcohol Use Disorders Identification Test (AUDIT). Secondary outcomes include: depression, anxiety, perceived stress, sleep quality, physical activity levels, fitness, self-efficacy, health-related quality of life, and cognition. Blood samples will be taken to objectively assess heavy drinking, and saliva to measure cortisol. Acute effects of exercise on the urge to drink alcohol, mood, and anxiety will also be assessed.Discussion: The treatment potential for exercise in AUDs is substantial as many individuals with the disorder are physically inactive and have comorbid health problems. The study is the first to assess the effects of physical activity as a stand-alone treatment for AUDs. Considerable attention will be given to optimizing exercise adherence. Both the feasibility and treatment effects of exercise interventions in AUDs will be discussed. The Ethical Review Board (EPN) at Karolinska Institutet has approved the study (DNR: 2017/1380-3).