WANTED DEAD OR ALIVE: New Thinking to Incentivize Drug Development
WANTED DEAD OR ALIVE: New Thinking to Incentivize Drug Development
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生死攸关：激励药物开发的新思维
DOI：
10.1007/s11095-024-03666-6
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发表时间：
2024
影响因子：
3.7
通讯作者：
Kinch, Michael S.
中科院分区：
文献类型：
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作者：
Kinch, Michael S.
尽管我们对疾病过程和靶向机会的理解取得了前所未有的进步，但我们发现和开发新药的持续能力从根本上受到质疑。这些挑战反映了老牌制药公司和投资者越来越认识到药物开发的风险（在资金和时间方面）不断上升。这些障碍是可以克服的，需要新的思维。这篇评论文章概述了这一挑战，并举例说明了我们如何通过对药物发现的建设性和前瞻性激励来克服这些挑战。
Despite unprecedented advancements in our understanding of disease process and targeting opportunities, our continued ability to discover and develop new medicines is fundamentally in doubt. These challenges reflect a growing recognition of the escalating risks of drug development (in terms of dollars and time) by established pharmaceutical companies and investors. Such hurdles are surmountable and require new thinking. This opinion piece conveys an overview of the challenge and an example of how we might overcome these challenges with constructive and forward-looking incentives for drug discovery.