Hydrodynamic and aerosol modelling of the rapid expansion of supercritical solutions (RESS-process)
Hydrodynamic and aerosol modelling of the rapid expansion of supercritical solutions (RESS-process)
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DOI：
10.1016/s0896-8446(02)00159-6
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发表时间：
2003-08-01
影响因子：
3.9
通讯作者：
Schaber, K
中科院分区：
文献类型：
--
作者：
Helfgen, B;Türk, M;Schaber, K
对超临界溶液(RESS过程)的快速膨胀进行了数值模拟，以更好地了解颗粒的形成和生长机制。建立了包括毛细喷嘴内的膨胀过程和膨胀室内颗粒长大的后膨胀过程的数学模型。结果显示，固体苯甲酸、灰黄霉素和β-谷甾醇与溶剂二氧化碳和三氟甲烷相结合。与实验结果的比较表明，总体趋势很好，但与测量的平均颗粒尺寸还不完全匹配。总体而言，已经创建了一个优化RESS过程的强大工具，这有助于理解RESS过程。(C)2002 Elsevier Science B.V.保留所有权利。
The rapid expansion of a supercritical solution (RESS-process) is modelled numerically to better understand the mechanisms of particle formation and growth. A model is presented which includes the expansion process inside the capillary nozzle as well as the post-expansion process with particle growth inside the expansion chamber. Results are shown for the solid benzoic acid, griseofulvin and beta-sitosterol in combination with the solvent carbon dioxide and trifluoromethane. The comparison with experimental results shows good agreement in general trends but does not yet match exactly with the measured mean particle sizes. Overall, a powerful tool for the optimisation of the RESS-process has been created which contributes to the understanding of the RESS-process. (C) 2002 Elsevier Science B.V. All rights reserved.