Biocompatible and biodegradable chitin-based hydrogels crosslinked by BDDE with excellent mechanical properties for effective prevention of postoperative peritoneal adhesion.
Biocompatible and biodegradable chitin-based hydrogels crosslinked by BDDE with excellent mechanical properties for effective prevention of postoperative peritoneal adhesion.
复制标题
生物相容性和生物可降解的甲壳素基水凝胶交联的BDDE具有良好的机械性能，有效地防止术后腹膜粘连。
DOI：
10.1016/j.carbpol.2023.120543
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发表时间：
2023-01
影响因子：
11.2
通讯作者：
Yongkang Zou;Pengpeng Yue;Hankun Cao;Liqin Wu;Li Xu;Zhongzhong Liu;Shuangquan Wu;Q. Ye
中科院分区：
文献类型：
--
作者：
Yongkang Zou;Pengpeng Yue;Hankun Cao;Liqin Wu;Li Xu;Zhongzhong Liu;Shuangquan Wu;Q. Ye
Postoperative peritoneal adhesions are common complications caused by abdominal and pelvic surgery, which seriously impact the quality of life of patients and impose additional financial burdens. Using of biomedical materials as physical barriers to completely isolate the traumatic organ and injured tissue is an optimal strategy for preventing postoperative adhesions. However, the limited efficacy and difficulties in the complete degradation or integration of biomedical materials with living tissues restrict the application of these materials. In this study, novel chitin-based crosslinked hydrogels with appropriate mechanical properties and flexibilities were developed using a facile and green strategy. The developed hydrogels simultaneously exhibited excellent biocompatibilities and resistance to nonspecific protein adsorption and NIH/3T3 fibroblast adhesion. Furthermore, these hydrogels were biodegradable and could be completely integrated into the native extracellular matrix. The chitin-based crosslinked hydrogels also effectively inhibited postoperative peritoneal adhesions in rat models of adhesion and recurrence. Therefore, these novel chitin-based crosslinked hydrogels are excellent candidate physical barriers for the efficient prevention of postoperative peritoneal adhesions and provide a new anti-adhesion strategy for biomedical applications.
