Sulforaphane shows remarkable growth inhibition and cytotoxicity against several human leukemia cell lines
Sulforaphane shows remarkable growth inhibition and cytotoxicity against several human leukemia cell lines
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发表时间：
2020
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通讯作者：
Sumiko Akiyoshi;H. Kikuchi;Hisanori Minami
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作者：
Sumiko Akiyoshi;H. Kikuchi;Hisanori Minami
萝卜硫素是一种典型的植物化学物质，是十字花科蔬菜（例如西兰花及其芽苗）的异硫氰酸酯衍生物。萝卜硫素可以保护高等植物免受各种生物入侵者（如蚜虫、蜱虫、细菌或线虫）的感染，同时它还对人体中的各种癌细胞表现出细胞毒性。然而，萝卜硫素对人类白血病细胞的影响目前尚未完全阐明。在本文中，我们研究了萝卜硫素对一些人白血病细胞系[Eol-1（嗜酸性白血病细胞系）、MOLT4（T 淋巴细胞系）、RPMI-1788（B 淋巴细胞系）和 U937（单核细胞白血病细胞系）增殖和活力的影响。萝卜硫素对这些细胞系表现出强烈的细胞毒性，从而以剂量依赖性方式抑制增殖。我们的数据表明萝卜硫素可以作为治疗各种类型白血病的有效药物。
Sulforaphane, a typical phytochemical, is an isothiocyanate derivative from cruciferous vegetables such as broccoli and its sprout. While sulforaphane protects higher plants from infections by various bio-invaders such as aphids, ticks, bacteria or nematodes, it shows cytotoxicity against various cancer cells in human body. However, the effects of sulforaphane on human leukemia cells are still incompletely elucidated now. In this paper, we examined the effects of sulforaphane on proliferation and viability of some human leukemia cell lines [Eol-1 (eosinophilic leukemia cell line), MOLT4 (T-lymphoblast cell line), RPMI-1788 (B-lymphoblastoid cell line) and U937 (monoblastic leukemia cell line). Sulforaphane showed strong cytotoxicity against these cell lines, resulting in inhibition of proliferation in a dose-dependent manner. Our data suggested that sulforaphane may serve as an effective agent for treatment of various types of leukemia.