Tissue expander capsule as an induced vascular bed to prefabricate an axial vascularized buccal mucosa-lined flap for tubularized posterior urethral reconstruction: preliminary results in an animal model.
Tissue expander capsule as an induced vascular bed to prefabricate an axial vascularized buccal mucosa-lined flap for tubularized posterior urethral reconstruction: preliminary results in an animal model.
复制标题
组织扩张器胶囊作为诱导血管床预制轴向血管化颊粘膜衬里皮瓣，用于管状后尿道重建：动物模型的初步结果。
DOI：
10.4103/aja.aja_133_19
复制
发表时间：
2020-09
影响因子：
2.9
通讯作者：
Chen F
中科院分区：
文献类型：
--
作者：
Guo HL;Wang L;Jia ZM;Bao XQ;Huang YC;Zhou JM;Xie H;Yang XJ;Chen F
Surgical repair of complex posterior urethral disruptions remains one of the most challenging problems in urology. The efficacy of using a tissue expander capsule as an induced vascular bed to prefabricate axial vascularized buccal mucosa-lined flaps for tubularized posterior urethral reconstruction in a rabbit model was tested. The experiments were performed in three stages. First, silicone tissue expanders were inserted into the groin to induce vascularized capsule pouch formation. Next, buccal mucosa grafts were transplanted into the newly formed capsular tissue supplied by axial vessels for buccal mucosa-lined flap prefabrication. Then, circumferential posterior urethral defects were created and repaired with the buccal mucosa graft (Group 1), the capsule flap (Group 2), and the prefabricated capsule buccal mucosa composite flap (Group 3). After surgery, notable contracture of the tubularized buccal mucosa graft was observed in the neourethra, and none of the rabbits in Group 1 maintained a wide urethral caliber. In Group 2, the retrieved neourethra showed little evidence of epithelial lining during the study period, and the lumen caliber was narrowed at the 3-month evaluation. In Group 3, the buccal mucosa formed the lining in the neourethra and maintained a wide urethral caliber for 3 months. The capsule may serve as an induced vascular bed for buccal mucosa-lined flap prefabrication. The prefabricated buccal mucosa-lined flap may serve as a neourethra flap for posterior urethral replacement.
登录
查看更多内容
影响因子：
2.1
作者：
Momeni, Arash;Bannasch, Holger
通讯作者：
Bannasch, Holger
影响因子：
2.3
作者：
Zan, Tao;Gao, Yashan;Li, Qingfeng
通讯作者：
Li, Qingfeng
影响因子：
168.9
作者：
Raya-Rivera, Atlantida;Esquiliano, Diego R.;Yoo, James J.;Lopez-Bayghen, Esther;Soker, Shay;Atala, Anthony
通讯作者：
Atala, Anthony
影响因子：
--
作者：
Nikolavsky, Dmitriy
通讯作者：
Nikolavsky, Dmitriy
影响因子：
6.6
作者：
WEBSTER, GD;MATHES, GL;SELLI, C
通讯作者：
SELLI, C