The neurochip: a new multielectrode device for stimulating and recording from cultured neurons
The neurochip: a new multielectrode device for stimulating and recording from cultured neurons
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DOI：
10.1016/s0165-0270(98)00156-3
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发表时间：
1999-02-01
影响因子：
3
通讯作者：
Tai, YC
中科院分区：
文献类型：
--
作者：
Maher, MP;Pine, J;Tai, YC
神经芯片是一种硅微机械装置，在其上培养的哺乳动物神经元可以被连续地和单独地监测和刺激。神经芯片基于4 × 4的金属电极阵列，每个电极都有一个笼状孔结构，设计用于容纳单个成熟细胞体，同时允许神经过程正常生长。我们证明了这种设备能够维持细胞存活，并且电极可以记录和刺激单个细胞中的电活动，通道之间没有串扰。(C)1999 Elsevier Science B.V.保留所有权利。
The neurochip is a silicon micromachined device upon which cultured mammalian neurons can be continuously and individually monitored and stimulated. The neurochip is based upon a 4 x 4 array of metal electrodes, each of which has a caged well structure designed to hold a single mature cell body while permitting normal outgrowth of neural processes. We demonstrate that this device is capable of maintaining cell survival, and that the electrodes can both record and stimulate electrical activity in individual cells with no crosstalk between channels. (C) 1999 Elsevier Science B.V. All rights reserved.