Subthalamic Nucleus Subregion Stimulation Modulates Inhibitory Control.
Subthalamic Nucleus Subregion Stimulation Modulates Inhibitory Control.
复制标题
DOI：
10.1093/texcom/tgaa083
复制
发表时间：
2020
影响因子：
--
通讯作者：
Wylie SA
中科院分区：
文献类型：
--
作者：
van Wouwe NC;Neimat JS;van den Wildenberg WPM;Hughes SB;Lopez AM;Phibbs FT;Schall JD;Rodriguez WJ;Bradley EB;Dawant BM;Wylie SA
帕金森氏症（PD）患者经常经历抑制动作熟练程度的降低。丘脑下核（STN）是额纹状体网络中的一个关键结构，可能直接参与抑制控制的调节，通过深部脑刺激（DBS）可以有效治疗PD的运动症状。然而，STN在停止控制中的确切作用尚不清楚。STN由与可分离的皮层网络相连的功能亚区域组成，尽管这些亚区域的边界仍在争论中。我们研究了刺激STN的背侧和腹侧亚区是否会对停止能力产生可分离的影响。我们研究了12例伴有STN DBS的PD患者。两个相邻触点位于STN背侧和腹侧边界内的患者在执行停止任务的同时，在双侧背侧或腹侧触点进行低振幅（0.4 mA）刺激，完成两次测试（OFF药物）。腹侧，而不是背侧，DBS改善了停止潜伏期。背侧和腹侧DBS STN之间的Go反应相似。刺激STN的腹侧亚区，而不是背侧亚区，提高了停止速度，证实了STN参与停止控制并支持STN功能亚区。
Patients with Parkinson’s disease (PD) often experience reductions in the proficiency to inhibit actions. The motor symptoms of PD can be effectively treated with deep brain stimulation (DBS) of the subthalamic nucleus (STN), a key structure in the frontal–striatal network that may be directly involved in regulating inhibitory control. However, the precise role of the STN in stopping control is unclear. The STN consists of functional subterritories linked to dissociable cortical networks, although the boundaries of the subregions are still under debate. We investigated whether stimulating the dorsal and ventral subregions of the STN would show dissociable effects on ability to stop. We studied 12 PD patients with STN DBS. Patients with two adjacent contacts positioned within the bounds of the dorsal and ventral STN completed two testing sessions (OFF medication) with low amplitude stimulation (0.4 mA) at either the dorsal or ventral contacts bilaterally, while performing the stop task. Ventral, but not dorsal, DBS improved stopping latencies. Go reactions were similar between dorsal and ventral DBS STN. Stimulation in the ventral, but not dorsal, subregion of the STN improved stopping speed, confirming the involvement of the STN in stopping control and supporting the STN functional subregions.