Clinical Characteristics of Young-Onset Ischemic Colitis
Clinical Characteristics of Young-Onset Ischemic Colitis
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DOI：
10.1007/s10620-012-2088-5
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发表时间：
2012-06-01
影响因子：
3.1
通讯作者：
Tanaka, Eiji
中科院分区：
文献类型：
--
作者：
Kimura, Takefumi;Shinji, Akihiro;Tanaka, Eiji
缺血性结肠炎（IC）通常发生在老年人中，其中高血压、心血管疾病和既往腹部手术史被认为是危险因素。虽然已经有年轻患者IC的报告，其临床特征仍不清楚。本研究的目的是澄清IC在年轻人的临床特征。359例患者被诊断为IC在5家医院在长野县，日本。比较年轻患者组[20-45岁，n = 53（15%）]和老年患者组[> 45岁，n = 306（85%）]的临床数据，以及年龄和性别匹配的健康个体（n = 156）。与老年患者组相比，年轻患者组中吸烟习惯和高尿酸血症的存在显著较高经多因素Logistic回归分析（P = 0.001，比值比3.239和P = 0.028，比值比16.907）证实。此外，对年轻IC患者组和年龄和性别匹配的健康个体的多元Logistic回归分析表明，这两个因素与IC的发展密切相关（P = 0.008，吸烟习惯的比值比为2.49，P = 0.039，高尿酸血症的优势比为6.37）。吸烟习惯和高尿酸血症的高患病率是年轻成人人群中IC的特征性特征。
Ischemic colitis (IC) typically develops in the elderly, where hypertension, cerebrocardiovascular disease, and past history of abdominal surgery are regarded as risk factors. Although there have been reports of younger patients with IC, its clinical features remain unclear.The aim of this study was to clarify the clinical characteristics of IC in young adults.Three hundred fifty-nine patients were diagnosed as having IC at five hospitals across Nagano prefecture, Japan. Clinical data were compared between the young patient group [20-45 years, n = 53 (15%)] and the elderly patient group [> 45 years, n = 306 (85%)], as well as with age- and gender-matched healthy individuals (n = 156).The presence of a smoking habit and hyperuricemia were significantly higher in the young patient group compared with the elderly patient group (42 vs. 19%, P = 0.001 and 8 vs. 1%, P = 0.019, respectively), which was confirmed by multiple logistic regression analysis (P = 0.001, odds ratio 3.239 and P = 0.028, odds ratio 16.907, respectively). Additionally, multiple logistic regression analysis of the young IC patient group and age- and gender-matched healthy individuals demonstrated that these two factors were strongly associated with IC development (P = 0.008, odds ratio 2.49 for smoking habit and P = 0.039, odds ratio 6.37 for hyperuricemia).High prevalences of a smoking habit and hyperuricemia are characteristic features of IC in the young adult population.