INCREASED FETOPLACENTAL ACTIVE RENIN PRODUCTION IN PREGNANCY-INDUCED HYPERTENSION
INCREASED FETOPLACENTAL ACTIVE RENIN PRODUCTION IN PREGNANCY-INDUCED HYPERTENSION
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DOI：
10.1016/s0002-9378(87)80173-4
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发表时间：
1987-08-01
影响因子：
9.8
通讯作者：
HSUEH, WA
中科院分区：
文献类型：
--
作者：
BRAR, HS;KJOS, SL;HSUEH, WA
由于妊娠高血压综合征与子宫胎盘血流受损有关，我们研究了对照组和妊娠高血压综合征患者胎儿胎盘和母体肾素的产生。我们测量了8名血压正常的足月患者和18名妊娠高血压患者的母体血清、胎儿动脉血和静脉血以及绒毛膜匀浆中的总、活性和非活性（前）肾素。正常妇女或妊娠高血压患者的母血中活性或前肾素无差异。与此相反，胎儿动脉和静脉，以及绒毛组织，含有显着较高的活性肾素在妊娠高血压综合征与正常人相比。两组胎儿或绒毛膜前肾素无差异。妊娠高血压综合征患者的胎儿和绒毛中活性肾素与总肾素的比例较高，这表明活性肾素的产生增加。这些结果表明，妊娠高血压综合征与胎儿胎盘单位的肾素-血管紧张素系统的活性增加，这是不反映在母体循环。这可能是胎儿和绒毛膜试图在子宫胎盘血流改变时维持血管稳态。
Since pregnancy-induced hypertension is associated with impaired uteroplacental blood flow, we studied fetoplacental and maternal renin production in controls and subjects with pregnancy-induced hypertension. We measured total, active, and inactive (pro-) renin in maternal serum, fetal arterial and venous blood, and chorion homogenate in eight normotensive term patients and 18 patients with pregnancy-induced hypertension. No differences in active or prorenin were found in maternal blood from normal women or patients with pregnancy-induced hypertension. In contrast, fetal artery and vein, as well as chorionic tissue, contained significantly higher active renin in pregnancy-induced hypertension compared with normal subjects. No difference in fetal or chorionic prorenin was seen in the two groups. The active to total renin ratio was higher in the fetus and chorion of subjects with pregnancy-induced hypertension, which suggests enhanced active renin production. These results suggest that pregnancy-induced hypertension is associated with increased activity of the renin-angiotensin system in the fetoplacental unit, which is not reflected in the maternal circulation. This may be an attempt by the fetus and chorionic membranes to maintain vascular homeostasis in the face of altered uteroplacental blood flow.