Mechanisms of pain in endometriosis
Mechanisms of pain in endometriosis
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DOI：
10.1016/j.ejogrb.2016.07.497
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发表时间：
2017-02-01
影响因子：
2.6
通讯作者：
Becker, Christian M.
中科院分区：
文献类型：
--
作者：
Morotti, Matteo;Vincent, Katy;Becker, Christian M.
疼痛是子宫内膜异位症的中心症状，尽管治疗，疼痛仍然存在。子宫内膜异位症相关疼痛的多种机制包括痛觉、炎症以及外周和中枢神经系统疼痛处理的改变。与其他慢性疾病一样，子宫内膜异位症的疼痛通常与心理困扰和疲劳有关，这两者都可能加剧疼痛。人们希望未来能够开发出基于潜在疼痛机制的女性表型方法，可能将临床症状和体征的关键评估与实验室和影像学检查相结合。如果她的特定的疼痛机制被确定并适当地解决，则更有可能实现个体的最佳疼痛缓解。这些方法还可以改善临床试验患者的选择，潜在地增加了许多子宫内膜异位症患者的新治疗方法的可能性，这些患者无法获得可接受的镇痛。2016爱思唯尔爱尔兰有限公司版权所有。
Pain is the central symptom in endometriosis and often persists despite treatment of the disease. Multiple mechanisms underlie endometriosis-associated pain including nociception, inflammation, and alterations in peripheral and central nervous system pain processing. As also occuring in other chronic conditions, pain in endometriosis is often associated with psychological distress and fatigue, both of which may amplify pain. It is hoped that in the future methods of phenotyping women on the basis of the underlying pain mechanisms will be developed, likely combining a critical evaluation of clinical symptoms and signs with laboratory and imaging tests. Optimal pain relief for an individual is more likely if her specific contributory pain mechanisms are identified and appropriately addressed. Such methods may also improve the selection of patients for clinical trials, potentially increasing the probability of identifying novel treatments for the many women with endometriosis for whom acceptable analgesia is not achieved. (C) 2016 Elsevier Ireland Ltd. All rights reserved.