Ethnicity/Race and Age-Specific Variations of Serum AMH in Women-A Review.
Ethnicity/Race and Age-Specific Variations of Serum AMH in Women-A Review.
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DOI：
10.3389/fendo.2020.593216
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发表时间：
2020
影响因子：
5.2
通讯作者：
Seifer DB
中科院分区：
文献类型：
--
作者：
Kotlyar AM;Seifer DB
在这篇综述中，我们总结了民族/种族和年龄相关的AMH的变化，并讨论这些差异背后的基础。抗苗勒管激素（AMH）在过去的15年中已成为一种广泛使用的卵巢储备测试方法。许多研究表明，种族/民族和年龄相关的差异很大。与年龄匹配的白人女性相比，黑人和西班牙裔女性的AMH水平往往较低。中国女性在25岁之前的AMH水平往往明显高于白人女性。当考虑种族内的亚群时，至少有一项研究指出，与其他西班牙裔妇女相比，玛雅妇女的AMH水平较低。年龄表现出AMH的积极趋势，直到至少25岁，34岁后持续下降，延伸到绝经期。AMH水平在种族和人种之间差异很大，通常在白人女性中看到较高的年龄匹配水平。年龄与抗苗勒氏管激素没有一致的线性关系，但在生命的第三个十年开始并继续到绝经期，可以看到一致的下降。
In this review, we summarize ethnic/race- and age-related variation in AMH and discuss the underpinnings behind these differences. Anti-mullerian hormone (AMH) has become a widely used method of ovarian reserve testing over the last 15 years. Numerous studies have shown substantial ethnic/race and age-related differences. When compared to age-matched Caucasian women, AMH levels tend to be lower in black and Hispanic women. Chinese women tend to have significantly greater AMH levels prior to age 25 than Caucasian women. When considering subpopulations within ethnicities, at least one study noted lower AMH levels among Maya women compared to other Hispanic women. Age exhibits a positive trend with AMH up until at least 25 years of age with a consistent decline after 34 years of age extending to menopause. AMH levels are highly variable among ethnicities and race with higher age-matched levels typically seen in Caucasian women. Age does not exhibit a consistent linear relationship with AMH, but a consistent decline is seen starting in the third decade of life and proceeding to menopause.