The inverse association between age and cholesterol level among older patients: The role of poor health status
The inverse association between age and cholesterol level among older patients: The role of poor health status
复制标题
DOI：
10.1159/000052768
复制
发表时间：
2001-01-01
期刊：
影响因子：
3.5
通讯作者：
Fellin, R
中科院分区：
文献类型：
--
作者：
Volpato, S;Zuliani, G;Fellin, R
背景：老年人的总胆固醇浓度随年龄增长而降低。这种现象的原因存在争议。本研究对健康状况不佳是老年人年龄与胆固醇呈负相关的决定因素这一假设进行了调查。
方法：对意大利老年药物警戒组（GIFA）在35个中心收治的2486名老年内科患者（≥65岁，其中53%为女性）进行横断面研究。总胆固醇在入院后第一天进行测量。疾病负担和合并症通过查尔森指数进行评估；低血清白蛋白和铁被视为虚弱和健康状况不佳的标志。
结果：男性中年龄与胆固醇存在显著的负相关关系（每年-0.97毫克/分升，p<0.001）。女性中这种关系呈非线性，75岁以后胆固醇显著降低（每年-0.95毫克/分升，p<0.005）。在多元线性回归分析中，健康状况不佳的指标在男性和女性中几乎占年龄对胆固醇水平原始影响的三分之二（年龄调整系数为：男性每年-0.38毫克/分升，p = 0.044；75岁以上女性每年-0.37毫克/分升，p = 0.205）。男性中胆固醇偏低的未调整概率随年龄显著增加（趋势p……（此处原文似乎不完整）
Background: The total cholesterol concentration decreases with age in older people. The reasons for this phenomenon are controversial. This study investigated the hypothesis that poor health status is a determinant of the inverse association between age and cholesterol in older persons. Methods: Cross-sectional study of 2,486 (53% women) older medical patients (greater than or equal to 65 years) admitted at 35 centers of the Gruppo Italiano di Farmacovigilanza nell'Anziano (GIFA) study in Italy. Total cholesterol was measured on the fi rst day after admission to the hospital. Disease burden and comorbidity were assessed by the Charlson index; low serum albumin and iron were considered markers of frailty and poor health. Results: In men there was a significant, inverse age-cholesterol relationship (-0.97 mg/dl per year, p < 0.001). In women the association was nonlinear and cholesterol significantly decreased after the age of 75 (-0.95 mg/dl per year, p < 0.005). In multiple linear regression analysis, indicators of poor health accounted for almost two thirds of the crude effect of age on the cholesterol level in both men and women (adjusted coefficients for age were: for men, -0.38 mg/dl per year, p = 0.044; for women after the age of 75, -0.37 mg/dl per year, p = 0.205). The unadjusted probability of having low cholesterol significantly increased with age among men (p for trend